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Functional screens refine height GWAS loci
Genome-wide association studies (GWASs) have demonstrated the complexity of human height. Baronas et al.(1) used a high-throughput CRISPR screen to identify genes that participate in growth plate chondrocyte maturation as a functional follow-up and validation screen to refine loci and establish caus...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203259/ https://www.ncbi.nlm.nih.gov/pubmed/37228748 http://dx.doi.org/10.1016/j.xgen.2023.100325 |
| _version_ | 1785045593472630784 |
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| author | Ackert-Bicknell, Cheryl L. |
| author_facet | Ackert-Bicknell, Cheryl L. |
| author_sort | Ackert-Bicknell, Cheryl L. |
| collection | PubMed |
| description | Genome-wide association studies (GWASs) have demonstrated the complexity of human height. Baronas et al.(1) used a high-throughput CRISPR screen to identify genes that participate in growth plate chondrocyte maturation as a functional follow-up and validation screen to refine loci and establish causality after GWASs. |
| format | Online Article Text |
| id | pubmed-10203259 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-102032592023-05-24 Functional screens refine height GWAS loci Ackert-Bicknell, Cheryl L. Cell Genom Preview Genome-wide association studies (GWASs) have demonstrated the complexity of human height. Baronas et al.(1) used a high-throughput CRISPR screen to identify genes that participate in growth plate chondrocyte maturation as a functional follow-up and validation screen to refine loci and establish causality after GWASs. Elsevier 2023-05-10 /pmc/articles/PMC10203259/ /pubmed/37228748 http://dx.doi.org/10.1016/j.xgen.2023.100325 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Preview Ackert-Bicknell, Cheryl L. Functional screens refine height GWAS loci |
| title | Functional screens refine height GWAS loci |
| title_full | Functional screens refine height GWAS loci |
| title_fullStr | Functional screens refine height GWAS loci |
| title_full_unstemmed | Functional screens refine height GWAS loci |
| title_short | Functional screens refine height GWAS loci |
| title_sort | functional screens refine height gwas loci |
| topic | Preview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203259/ https://www.ncbi.nlm.nih.gov/pubmed/37228748 http://dx.doi.org/10.1016/j.xgen.2023.100325 |
| work_keys_str_mv | AT ackertbicknellcheryll functionalscreensrefineheightgwasloci |