Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential

Current approaches to staging chronic liver diseases have limited utility for predicting liver cancer risk. Here, we employed single-nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and pre-malignant livers using two distinct mouse models. Downstream analys...

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Detalles Bibliográficos
Autores principales: Carlessi, Rodrigo, Denisenko, Elena, Boslem, Ebru, Köhn-Gaone, Julia, Main, Nathan, Abu Bakar, N. Dianah B., Shirolkar, Gayatri D., Jones, Matthew, Beasley, Aaron B., Poppe, Daniel, Dwyer, Benjamin J., Jackaman, Connie, Tjiam, M. Christian, Lister, Ryan, Karin, Michael, Fallowfield, Jonathan A., Kendall, Timothy J., Forbes, Stuart J., Gray, Elin S., Olynyk, John K., Yeoh, George, Forrest, Alistair R.R., Ramm, Grant A., Febbraio, Mark A., Tirnitz-Parker, Janina E.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203275/
https://www.ncbi.nlm.nih.gov/pubmed/37228755
http://dx.doi.org/10.1016/j.xgen.2023.100301

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