Systematic elucidation of genetic mechanisms underlying cholesterol uptake

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Genetic variation contributes greatly to LDL cholesterol (LDL-C) levels and coronary artery disease risk. By combining analysis of rare coding variants from the UK Biobank and genome-scale CRISPR-Cas9 knockout and activation screening, we substantially improve the identification of genes whose disru...

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Detalles Bibliográficos
Autores principales: Hamilton, Marisa C., Fife, James D., Akinci, Ersin, Yu, Tian, Khowpinitchai, Benyapa, Cha, Minsun, Barkal, Sammy, Thi, Thi Tun, Yeo, Grace H.T., Ramos Barroso, Juan Pablo, Francoeur, Matthew Jake, Velimirovic, Minja, Gifford, David K., Lettre, Guillaume, Yu, Haojie, Cassa, Christopher A., Sherwood, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203276/
https://www.ncbi.nlm.nih.gov/pubmed/37228746
http://dx.doi.org/10.1016/j.xgen.2023.100304
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