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Upregulation of breathing rate during running exercise by central locomotor circuits in mice
While respiratory adaptation to exercise is compulsory to cope with the increased metabolic demand, the neural signals at stake remain poorly identified. Using neural circuit tracing and activity interference strategies in mice, we uncover here two systems by which the central locomotor network can...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203288/ https://www.ncbi.nlm.nih.gov/pubmed/37217517 http://dx.doi.org/10.1038/s41467-023-38583-6 |
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author | Hérent, Coralie Diem, Séverine Usseglio, Giovanni Fortin, Gilles Bouvier, Julien |
author_facet | Hérent, Coralie Diem, Séverine Usseglio, Giovanni Fortin, Gilles Bouvier, Julien |
author_sort | Hérent, Coralie |
collection | PubMed |
description | While respiratory adaptation to exercise is compulsory to cope with the increased metabolic demand, the neural signals at stake remain poorly identified. Using neural circuit tracing and activity interference strategies in mice, we uncover here two systems by which the central locomotor network can enable respiratory augmentation in relation to running activity. One originates in the mesencephalic locomotor region (MLR), a conserved locomotor controller. Through direct projections onto the neurons of the preBötzinger complex that generate the inspiratory rhythm, the MLR can trigger a moderate increase of respiratory frequency, prior to, or even in the absence of, locomotion. The other is the lumbar enlargement of the spinal cord containing the hindlimb motor circuits. When activated, and through projections onto the retrotrapezoid nucleus (RTN), it also potently upregulates breathing rate. On top of identifying critical underpinnings for respiratory hyperpnea, these data also expand the functional implication of cell types and pathways that are typically regarded as “locomotor” or “respiratory” related. |
format | Online Article Text |
id | pubmed-10203288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102032882023-05-24 Upregulation of breathing rate during running exercise by central locomotor circuits in mice Hérent, Coralie Diem, Séverine Usseglio, Giovanni Fortin, Gilles Bouvier, Julien Nat Commun Article While respiratory adaptation to exercise is compulsory to cope with the increased metabolic demand, the neural signals at stake remain poorly identified. Using neural circuit tracing and activity interference strategies in mice, we uncover here two systems by which the central locomotor network can enable respiratory augmentation in relation to running activity. One originates in the mesencephalic locomotor region (MLR), a conserved locomotor controller. Through direct projections onto the neurons of the preBötzinger complex that generate the inspiratory rhythm, the MLR can trigger a moderate increase of respiratory frequency, prior to, or even in the absence of, locomotion. The other is the lumbar enlargement of the spinal cord containing the hindlimb motor circuits. When activated, and through projections onto the retrotrapezoid nucleus (RTN), it also potently upregulates breathing rate. On top of identifying critical underpinnings for respiratory hyperpnea, these data also expand the functional implication of cell types and pathways that are typically regarded as “locomotor” or “respiratory” related. Nature Publishing Group UK 2023-05-22 /pmc/articles/PMC10203288/ /pubmed/37217517 http://dx.doi.org/10.1038/s41467-023-38583-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hérent, Coralie Diem, Séverine Usseglio, Giovanni Fortin, Gilles Bouvier, Julien Upregulation of breathing rate during running exercise by central locomotor circuits in mice |
title | Upregulation of breathing rate during running exercise by central locomotor circuits in mice |
title_full | Upregulation of breathing rate during running exercise by central locomotor circuits in mice |
title_fullStr | Upregulation of breathing rate during running exercise by central locomotor circuits in mice |
title_full_unstemmed | Upregulation of breathing rate during running exercise by central locomotor circuits in mice |
title_short | Upregulation of breathing rate during running exercise by central locomotor circuits in mice |
title_sort | upregulation of breathing rate during running exercise by central locomotor circuits in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203288/ https://www.ncbi.nlm.nih.gov/pubmed/37217517 http://dx.doi.org/10.1038/s41467-023-38583-6 |
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