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IDO-1 inhibitor INCB24360 elicits distant metastasis of basal extruded cancer cells in pancreatic ductal adenocarcinoma

Neoplastic cells of non-immunogenic pancreatic ductal adenocarcinoma (PDAC) express indoleamine 2,3-dioxygenase 1 (IDO-1), an immunosuppressive enzyme. The metabolites of IDO-1 in cancers provide one-carbon units that annihilate effector T cells, and recruit immunosuppressive cells. In this study we...

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Detalles Bibliográficos
Autores principales:	Buhe, Hada, Ma, Ji-xin, Ye, Fang-zhou, Song, Chen-yun, Chen, Xin-yu, Liu, Yang, Lin, Huang, Han, Xu, Ma, Li-xiang, Saiyin, Hexige
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203339/ https://www.ncbi.nlm.nih.gov/pubmed/36517670 http://dx.doi.org/10.1038/s41401-022-01035-w

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