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Differences in the phenotypes and transcriptomic signatures of chimeric antigen receptor T lymphocytes manufactured via electroporation or lentiviral transfection

Chimeric antigen receptor (CAR)-T cell therapy is an innovative treatment for CD19-expressing lymphomas. CAR-T cells are primarily manufactured via lentivirus transfection or transposon electroporation. While anti-tumor efficacy comparisons between the two methods have been conducted, there is a cur...

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Detalles Bibliográficos
Autores principales:	Niu, Anna, Zou, Jintao, Hu, Xuan, Zhang, Zhang, Su, Lingyu, Wang, Jing, Lu, Xing, Zhang, Wei, Chen, Wei, Zhang, Xiaopeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203401/ https://www.ncbi.nlm.nih.gov/pubmed/37228617 http://dx.doi.org/10.3389/fimmu.2023.1068625

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