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Prolonged mechanical ventilation after lung transplantation: risks factors and consequences on recipient outcome
BACKGROUND: Risk factors and the incidence of prolonged mechanical ventilation (PMV) after lung transplantation (LT) have been poorly described. The study assessed predictive factors of PMV after LT. METHODS: This observational, retrospective, monocentric study included all patients who received LT...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203407/ https://www.ncbi.nlm.nih.gov/pubmed/37228395 http://dx.doi.org/10.3389/fmed.2023.1160621 |
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author | Atchade, Enora Boughaba, Aimane Dinh, Alexy Tran Jean-Baptiste, Sylvain Tanaka, Sébastien Copelovici, Léa Lortat-Jacob, Brice Roussel, Arnaud Castier, Yves Messika, Jonathan Mal, Hervé de Tymowski, Christian Montravers, Philippe |
author_facet | Atchade, Enora Boughaba, Aimane Dinh, Alexy Tran Jean-Baptiste, Sylvain Tanaka, Sébastien Copelovici, Léa Lortat-Jacob, Brice Roussel, Arnaud Castier, Yves Messika, Jonathan Mal, Hervé de Tymowski, Christian Montravers, Philippe |
author_sort | Atchade, Enora |
collection | PubMed |
description | BACKGROUND: Risk factors and the incidence of prolonged mechanical ventilation (PMV) after lung transplantation (LT) have been poorly described. The study assessed predictive factors of PMV after LT. METHODS: This observational, retrospective, monocentric study included all patients who received LT in Bichat Claude Bernard Hospital between January 2016 and December 2020. PMV was defined as a duration of MV > 14 days. Independent risk factors for PMV were studied using multivariate analysis. One-year survival depending on PMV was studied using Kaplan Meier and log-rank tests. A p value <0.05 was defined as significant. RESULTS: 224 LT recipients were analysed. 64 (28%) of them received PMV for a median duration of 34 [26–52] days versus 2 [1–3] days without PMV. Independent risk factors for PMV were higher body mass index (BMI) (p = 0.031), diabetes mellitus of the recipient (p = 0.039), ECMO support during surgery (p = 0.029) and intraoperative transfusion >5 red blood cell units (p < 0.001). Increased mortality rates were observed at one-year in recipients who received PMV (44% versus 15%, p < 0.001). CONCLUSION: PMV was associated with increased morbidity and mortality one-year after LT. Preoperative risk factors (BMI and diabetes mellitus) must be considered when selecting and conditioning the recipients. |
format | Online Article Text |
id | pubmed-10203407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102034072023-05-24 Prolonged mechanical ventilation after lung transplantation: risks factors and consequences on recipient outcome Atchade, Enora Boughaba, Aimane Dinh, Alexy Tran Jean-Baptiste, Sylvain Tanaka, Sébastien Copelovici, Léa Lortat-Jacob, Brice Roussel, Arnaud Castier, Yves Messika, Jonathan Mal, Hervé de Tymowski, Christian Montravers, Philippe Front Med (Lausanne) Medicine BACKGROUND: Risk factors and the incidence of prolonged mechanical ventilation (PMV) after lung transplantation (LT) have been poorly described. The study assessed predictive factors of PMV after LT. METHODS: This observational, retrospective, monocentric study included all patients who received LT in Bichat Claude Bernard Hospital between January 2016 and December 2020. PMV was defined as a duration of MV > 14 days. Independent risk factors for PMV were studied using multivariate analysis. One-year survival depending on PMV was studied using Kaplan Meier and log-rank tests. A p value <0.05 was defined as significant. RESULTS: 224 LT recipients were analysed. 64 (28%) of them received PMV for a median duration of 34 [26–52] days versus 2 [1–3] days without PMV. Independent risk factors for PMV were higher body mass index (BMI) (p = 0.031), diabetes mellitus of the recipient (p = 0.039), ECMO support during surgery (p = 0.029) and intraoperative transfusion >5 red blood cell units (p < 0.001). Increased mortality rates were observed at one-year in recipients who received PMV (44% versus 15%, p < 0.001). CONCLUSION: PMV was associated with increased morbidity and mortality one-year after LT. Preoperative risk factors (BMI and diabetes mellitus) must be considered when selecting and conditioning the recipients. Frontiers Media S.A. 2023-05-09 /pmc/articles/PMC10203407/ /pubmed/37228395 http://dx.doi.org/10.3389/fmed.2023.1160621 Text en Copyright © 2023 Atchade, Boughaba, Dinh, Jean-Baptiste, Tanaka, Copelovici, Lortat-Jacob, Roussel, Castier, Messika, Mal, Tymowski and Montravers. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Atchade, Enora Boughaba, Aimane Dinh, Alexy Tran Jean-Baptiste, Sylvain Tanaka, Sébastien Copelovici, Léa Lortat-Jacob, Brice Roussel, Arnaud Castier, Yves Messika, Jonathan Mal, Hervé de Tymowski, Christian Montravers, Philippe Prolonged mechanical ventilation after lung transplantation: risks factors and consequences on recipient outcome |
title | Prolonged mechanical ventilation after lung transplantation: risks factors and consequences on recipient outcome |
title_full | Prolonged mechanical ventilation after lung transplantation: risks factors and consequences on recipient outcome |
title_fullStr | Prolonged mechanical ventilation after lung transplantation: risks factors and consequences on recipient outcome |
title_full_unstemmed | Prolonged mechanical ventilation after lung transplantation: risks factors and consequences on recipient outcome |
title_short | Prolonged mechanical ventilation after lung transplantation: risks factors and consequences on recipient outcome |
title_sort | prolonged mechanical ventilation after lung transplantation: risks factors and consequences on recipient outcome |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203407/ https://www.ncbi.nlm.nih.gov/pubmed/37228395 http://dx.doi.org/10.3389/fmed.2023.1160621 |
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