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Pathophysiological role of BACH transcription factors in digestive system diseases

BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are transcription factors that are widely expressed in human tissues. BACH proteins form heterodimers with small musculoaponeurotic fibrosarcoma (MAF) proteins to suppress the transcription of target genes. Furthermore, BACH1 promote...

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Autores principales: Song, Qianben, Mao, Xin, Jing, Mengjia, Fu, Yu, Yan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203417/
https://www.ncbi.nlm.nih.gov/pubmed/37228820
http://dx.doi.org/10.3389/fphys.2023.1121353
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author Song, Qianben
Mao, Xin
Jing, Mengjia
Fu, Yu
Yan, Wei
author_facet Song, Qianben
Mao, Xin
Jing, Mengjia
Fu, Yu
Yan, Wei
author_sort Song, Qianben
collection PubMed
description BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are transcription factors that are widely expressed in human tissues. BACH proteins form heterodimers with small musculoaponeurotic fibrosarcoma (MAF) proteins to suppress the transcription of target genes. Furthermore, BACH1 promotes the transcription of target genes. BACH proteins regulate physiological processes, such as the differentiation of B cells and T cells, mitochondrial function, and heme homeostasis as well as pathogenesis related to inflammation, oxidative-stress damage caused by drugs, toxicants, or infections; autoimmunity disorders; and cancer angiogenesis, epithelial-mesenchymal transition, chemotherapy resistance, progression, and metabolism. In this review, we discuss the function of BACH proteins in the digestive system, including the liver, gallbladder, esophagus, stomach, small and large intestines, and pancreas. BACH proteins directly target genes or indirectly regulate downstream molecules to promote or inhibit biological phenomena such as inflammation, tumor angiogenesis, and epithelial-mesenchymal transition. BACH proteins are also regulated by proteins, miRNAs, LncRNAs, labile iron, and positive and negative feedback. Additionally, we summarize a list of regulators targeting these proteins. Our review provides a reference for future studies on targeted drugs in digestive diseases.
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spelling pubmed-102034172023-05-24 Pathophysiological role of BACH transcription factors in digestive system diseases Song, Qianben Mao, Xin Jing, Mengjia Fu, Yu Yan, Wei Front Physiol Physiology BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are transcription factors that are widely expressed in human tissues. BACH proteins form heterodimers with small musculoaponeurotic fibrosarcoma (MAF) proteins to suppress the transcription of target genes. Furthermore, BACH1 promotes the transcription of target genes. BACH proteins regulate physiological processes, such as the differentiation of B cells and T cells, mitochondrial function, and heme homeostasis as well as pathogenesis related to inflammation, oxidative-stress damage caused by drugs, toxicants, or infections; autoimmunity disorders; and cancer angiogenesis, epithelial-mesenchymal transition, chemotherapy resistance, progression, and metabolism. In this review, we discuss the function of BACH proteins in the digestive system, including the liver, gallbladder, esophagus, stomach, small and large intestines, and pancreas. BACH proteins directly target genes or indirectly regulate downstream molecules to promote or inhibit biological phenomena such as inflammation, tumor angiogenesis, and epithelial-mesenchymal transition. BACH proteins are also regulated by proteins, miRNAs, LncRNAs, labile iron, and positive and negative feedback. Additionally, we summarize a list of regulators targeting these proteins. Our review provides a reference for future studies on targeted drugs in digestive diseases. Frontiers Media S.A. 2023-05-09 /pmc/articles/PMC10203417/ /pubmed/37228820 http://dx.doi.org/10.3389/fphys.2023.1121353 Text en Copyright © 2023 Song, Mao, Jing, Fu and Yan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Song, Qianben
Mao, Xin
Jing, Mengjia
Fu, Yu
Yan, Wei
Pathophysiological role of BACH transcription factors in digestive system diseases
title Pathophysiological role of BACH transcription factors in digestive system diseases
title_full Pathophysiological role of BACH transcription factors in digestive system diseases
title_fullStr Pathophysiological role of BACH transcription factors in digestive system diseases
title_full_unstemmed Pathophysiological role of BACH transcription factors in digestive system diseases
title_short Pathophysiological role of BACH transcription factors in digestive system diseases
title_sort pathophysiological role of bach transcription factors in digestive system diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203417/
https://www.ncbi.nlm.nih.gov/pubmed/37228820
http://dx.doi.org/10.3389/fphys.2023.1121353
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