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Pathophysiological role of BACH transcription factors in digestive system diseases
BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are transcription factors that are widely expressed in human tissues. BACH proteins form heterodimers with small musculoaponeurotic fibrosarcoma (MAF) proteins to suppress the transcription of target genes. Furthermore, BACH1 promote...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203417/ https://www.ncbi.nlm.nih.gov/pubmed/37228820 http://dx.doi.org/10.3389/fphys.2023.1121353 |
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author | Song, Qianben Mao, Xin Jing, Mengjia Fu, Yu Yan, Wei |
author_facet | Song, Qianben Mao, Xin Jing, Mengjia Fu, Yu Yan, Wei |
author_sort | Song, Qianben |
collection | PubMed |
description | BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are transcription factors that are widely expressed in human tissues. BACH proteins form heterodimers with small musculoaponeurotic fibrosarcoma (MAF) proteins to suppress the transcription of target genes. Furthermore, BACH1 promotes the transcription of target genes. BACH proteins regulate physiological processes, such as the differentiation of B cells and T cells, mitochondrial function, and heme homeostasis as well as pathogenesis related to inflammation, oxidative-stress damage caused by drugs, toxicants, or infections; autoimmunity disorders; and cancer angiogenesis, epithelial-mesenchymal transition, chemotherapy resistance, progression, and metabolism. In this review, we discuss the function of BACH proteins in the digestive system, including the liver, gallbladder, esophagus, stomach, small and large intestines, and pancreas. BACH proteins directly target genes or indirectly regulate downstream molecules to promote or inhibit biological phenomena such as inflammation, tumor angiogenesis, and epithelial-mesenchymal transition. BACH proteins are also regulated by proteins, miRNAs, LncRNAs, labile iron, and positive and negative feedback. Additionally, we summarize a list of regulators targeting these proteins. Our review provides a reference for future studies on targeted drugs in digestive diseases. |
format | Online Article Text |
id | pubmed-10203417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102034172023-05-24 Pathophysiological role of BACH transcription factors in digestive system diseases Song, Qianben Mao, Xin Jing, Mengjia Fu, Yu Yan, Wei Front Physiol Physiology BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are transcription factors that are widely expressed in human tissues. BACH proteins form heterodimers with small musculoaponeurotic fibrosarcoma (MAF) proteins to suppress the transcription of target genes. Furthermore, BACH1 promotes the transcription of target genes. BACH proteins regulate physiological processes, such as the differentiation of B cells and T cells, mitochondrial function, and heme homeostasis as well as pathogenesis related to inflammation, oxidative-stress damage caused by drugs, toxicants, or infections; autoimmunity disorders; and cancer angiogenesis, epithelial-mesenchymal transition, chemotherapy resistance, progression, and metabolism. In this review, we discuss the function of BACH proteins in the digestive system, including the liver, gallbladder, esophagus, stomach, small and large intestines, and pancreas. BACH proteins directly target genes or indirectly regulate downstream molecules to promote or inhibit biological phenomena such as inflammation, tumor angiogenesis, and epithelial-mesenchymal transition. BACH proteins are also regulated by proteins, miRNAs, LncRNAs, labile iron, and positive and negative feedback. Additionally, we summarize a list of regulators targeting these proteins. Our review provides a reference for future studies on targeted drugs in digestive diseases. Frontiers Media S.A. 2023-05-09 /pmc/articles/PMC10203417/ /pubmed/37228820 http://dx.doi.org/10.3389/fphys.2023.1121353 Text en Copyright © 2023 Song, Mao, Jing, Fu and Yan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Song, Qianben Mao, Xin Jing, Mengjia Fu, Yu Yan, Wei Pathophysiological role of BACH transcription factors in digestive system diseases |
title | Pathophysiological role of BACH transcription factors in digestive system diseases |
title_full | Pathophysiological role of BACH transcription factors in digestive system diseases |
title_fullStr | Pathophysiological role of BACH transcription factors in digestive system diseases |
title_full_unstemmed | Pathophysiological role of BACH transcription factors in digestive system diseases |
title_short | Pathophysiological role of BACH transcription factors in digestive system diseases |
title_sort | pathophysiological role of bach transcription factors in digestive system diseases |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203417/ https://www.ncbi.nlm.nih.gov/pubmed/37228820 http://dx.doi.org/10.3389/fphys.2023.1121353 |
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