A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

Despite substantial improvements in the treatment landscape of prostate cancer, the evolution of hormone therapy-resistant and metastatic prostate cancer remains a major cause of cancer-related death globally. The mainstay of treatment for advanced prostate cancer is targeting of androgen receptor s...

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Detalles Bibliográficos
Autores principales: Ware, Kathryn E., Thomas, Beatrice C., Olawuni, Pelumi D., Sheth, Maya U., Hawkey, Nathan, Yeshwanth, M., Miller, Brian C., Vietor, Katherine J., Jolly, Mohit Kumar, Kim, So Young, Armstrong, Andrew J., Somarelli, Jason A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203420/
https://www.ncbi.nlm.nih.gov/pubmed/37228586
http://dx.doi.org/10.3389/fmolb.2023.1104505

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