Cargando…

“Huoling Shengji granule” for amyotrophic lateral sclerosis: protocol for a multicenter, randomized, double-blind, riluzole parallel controlled clinical trial

BACKGROUND: There is still a large demand for effective treatments to delay disease deterioration in amyotrophic lateral sclerosis (ALS). Typical symptoms of ALS are considered “flaccidity syndrome” in traditional Chinese medicine (TCM). Huoling Shengji Granule (HLSJ) is a TCM formula used to treat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Xiaolu, Qin, Tingting, Li, Tao, Shan, Lei, Lei, Xiang, Xu, Xin, Wen, Bin, Feng, Yi, Yin, Ping, Fan, Dongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203426/ https://www.ncbi.nlm.nih.gov/pubmed/37228252 http://dx.doi.org/10.3389/fnagi.2023.1153973

Ejemplares similares

Similarity Evaluation on the Compound TCM Formulation “Huoling Shengji Granule” and Its Placebo by Intelligent Sensory Evaluation Technologies and the Human Sensory Evaluation Method Based on Critical Quality Attributes
por: Wu, Mei, et al.
Publicado: (2021)

Riluzole and Edavarone: The Hope Against Amyotrophic Lateral Sclerosis
por: Rokade, Aditi V, et al.
Publicado: (2022)

Adherence to riluzole in patients with amyotrophic lateral sclerosis: an observational study
por: Introna, Alessandro, et al.
Publicado: (2018)

MRI Volumetric Analysis of the Thalamus and Hypothalamus in Amyotrophic Lateral Sclerosis
por: Ye, Shan, et al.
Publicado: (2022)

Riluzole is associated with decreasing neuritic plaque severity in amyotrophic lateral sclerosis
por: Mazumder, Srestha, et al.
Publicado: (2022)

A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis
por: Dupuis, Luc, et al.
Publicado: (2012)

Long-Term Use of Riluzole Could Improve the Prognosis of Sporadic Amyotrophic Lateral Sclerosis Patients: A Real-World Cohort Study in China
por: Chen, Lu, et al.
Publicado: (2016)

Riluzole prescribing, uptake and treatment discontinuation in people with amyotrophic lateral sclerosis in Scotland
por: Jayaprakash, Kiran, et al.
Publicado: (2020)

Administration of Riluzole Oral Suspension During the Different Stages of Amyotrophic Lateral Sclerosis
por: Povedano Panades, Mónica, et al.
Publicado: (2021)

Early initiation of riluzole may improve absolute survival in amyotrophic lateral sclerosis
por: Thakore, Nimish J., et al.
Publicado: (2022)

Riluzole Selective Antioxidant Effects in Cell Models Expressing Amyotrophic Lateral Sclerosis Endophenotypes
por: Sala, Gessica, et al.
Publicado: (2019)

Dysphagia in Amyotrophic Lateral Sclerosis: Impact on Patient Behavior, Diet Adaptation, and Riluzole Management
por: Onesti, Emanuela, et al.
Publicado: (2017)

Assessment of Therapeutic Response of Edaravone and Riluzole Combination Therapy in Amyotrophic Lateral Sclerosis Patients
por: Samadhiya, Swapnil, et al.
Publicado: (2022)

Selective and Inverse U-Shaped Curve Alteration of the Retinal Nerve in Amyotrophic Lateral Sclerosis: A Potential Mirror of the Disease
por: Zhang, Yixuan, et al.
Publicado: (2022)

Association of cerebral spinal fluid copper imbalance in amyotrophic lateral sclerosis
por: Chen, Qiao Yi, et al.
Publicado: (2022)

Potential roles of the endoplasmic reticulum stress pathway in amyotrophic lateral sclerosis
por: Jeon, Yu-Mi, et al.
Publicado: (2023)

Serum chloride as a respiratory failure marker in amyotrophic lateral sclerosis
por: Manera, Umberto, et al.
Publicado: (2023)

Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients
por: Deflorio, Cristina, et al.
Publicado: (2014)

Riluzole–Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis
por: Albertini, Claudia, et al.
Publicado: (2022)

Phenotypic correlates of serum neurofilament light chain levels in amyotrophic lateral sclerosis
por: Verde, Federico, et al.
Publicado: (2023)

Stress Granule Dysregulation in Amyotrophic Lateral Sclerosis
por: Dudman, Jessica, et al.
Publicado: (2020)

Riluzole 5 mg/mL oral suspension: for optimized drug delivery in amyotrophic lateral sclerosis
por: Dyer, Ann Margaret, et al.
Publicado: (2016)

Towards Understanding the Relationship Between ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis
por: Zhao, Chenxuan, et al.
Publicado: (2022)

Genetic and clinical analysis of TP73 gene in amyotrophic lateral sclerosis patients from Chinese mainland
por: Tang, Xuxiong, et al.
Publicado: (2023)

Riluzole: real-world evidence supports significant extension of median survival times in patients with amyotrophic lateral sclerosis
por: Hinchcliffe, Michael, et al.
Publicado: (2017)

From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies
por: Mignani, Serge, et al.
Publicado: (2020)

In silico studies reveal structural deviations of mutant profilin-1 and interaction with riluzole and edaravone in amyotrophic lateral sclerosis
por: Sadr, Ahmad Shahir, et al.
Publicado: (2021)

Functional connectivity–based prediction of global cognition and motor function in riluzole-naive amyotrophic lateral sclerosis patients
por: Wei, Luqing, et al.
Publicado: (2022)

Repeated neurofilament light chain measurements did not capture Riluzole therapeutic effect in amyotrophic lateral sclerosis patients
por: Esselin, Florence, et al.
Publicado: (2022)

Amyotrophic lateral sclerosis in seven provinces of Chinese mainland: A cross-sectional survey from 2015 to 2016
por: Zhang, Jie, et al.
Publicado: (2022)

Association of the risk factor UNC13A with survival and upper motor neuron involvement in amyotrophic lateral sclerosis
por: Manini, Arianna, et al.
Publicado: (2023)

Shengjie Tongyu Granule Inhibits Vascular Remodeling in ApoE-Gene-Knockout Mice
por: Chen, Min, et al.
Publicado: (2012)

Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform
por: Pun, Frank W., et al.
Publicado: (2022)

Interstitial pneumonia and other adverse events in riluzole-administered amyotrophic lateral sclerosis patients: a retrospective observational study
por: Inoue-Shibui, Aya, et al.
Publicado: (2019)

Dynamic Alterations in Functional Connectivity Density in Amyotrophic Lateral Sclerosis: A Resting-State Functional Magnetic Resonance Imaging Study
por: Shi, Jia-Yan, et al.
Publicado: (2022)

Mixed Comparison of Different Exercise Interventions for Function, Respiratory, Fatigue, and Quality of Life in Adults With Amyotrophic Lateral Sclerosis: Systematic Review and Network Meta-Analysis
por: Zhu, Yining, et al.
Publicado: (2022)

Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis
por: Keifer, Orion P., et al.
Publicado: (2023)

DCTN1 gene analysis in Chinese patients with sporadic amyotrophic lateral sclerosis
por: Liu, Xiangyi, et al.
Publicado: (2017)

A multicenter, randomized, double blind, placebo-controlled clinical trial of DL-3-n-butylphthalide in treatment of amyotrophic lateral sclerosis
por: Liu, Mingsheng, et al.
Publicado: (2023)

A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations
por: Allen, Scott P., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6d7htr4ec1mrc93nplpln3geas