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Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway

Hematopoietic stem cells (HSCs) are important for the hematopoietic system because they can self-renew to increase their number and differentiate into all the blood cells. At a steady state, most of the HSCs remain in quiescence to preserve their capacities and protect themselves from damage and exh...

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Autores principales: Ling, Bai, Xu, Yunyang, Qian, Siyuan, Xiang, Ze, Xuan, Shihai, Wu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203478/
https://www.ncbi.nlm.nih.gov/pubmed/37228652
http://dx.doi.org/10.3389/fcell.2023.1186850
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author Ling, Bai
Xu, Yunyang
Qian, Siyuan
Xiang, Ze
Xuan, Shihai
Wu, Jian
author_facet Ling, Bai
Xu, Yunyang
Qian, Siyuan
Xiang, Ze
Xuan, Shihai
Wu, Jian
author_sort Ling, Bai
collection PubMed
description Hematopoietic stem cells (HSCs) are important for the hematopoietic system because they can self-renew to increase their number and differentiate into all the blood cells. At a steady state, most of the HSCs remain in quiescence to preserve their capacities and protect themselves from damage and exhaustive stress. However, when there are some emergencies, HSCs are activated to start their self-renewal and differentiation. The mTOR signaling pathway has been shown as an important signaling pathway that can regulate the differentiation, self-renewal, and quiescence of HSCs, and many types of molecules can regulate HSCs’ these three potentials by influencing the mTOR signaling pathway. Here we review how mTOR signaling pathway regulates HSCs three potentials, and introduce some molecules that can work as the regulator of HSCs’ these potentials through the mTOR signaling. Finally, we outline the clinical significance of studying the regulation of HSCs three potentials through the mTOR signaling pathway and make some predictions.
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spelling pubmed-102034782023-05-24 Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway Ling, Bai Xu, Yunyang Qian, Siyuan Xiang, Ze Xuan, Shihai Wu, Jian Front Cell Dev Biol Cell and Developmental Biology Hematopoietic stem cells (HSCs) are important for the hematopoietic system because they can self-renew to increase their number and differentiate into all the blood cells. At a steady state, most of the HSCs remain in quiescence to preserve their capacities and protect themselves from damage and exhaustive stress. However, when there are some emergencies, HSCs are activated to start their self-renewal and differentiation. The mTOR signaling pathway has been shown as an important signaling pathway that can regulate the differentiation, self-renewal, and quiescence of HSCs, and many types of molecules can regulate HSCs’ these three potentials by influencing the mTOR signaling pathway. Here we review how mTOR signaling pathway regulates HSCs three potentials, and introduce some molecules that can work as the regulator of HSCs’ these potentials through the mTOR signaling. Finally, we outline the clinical significance of studying the regulation of HSCs three potentials through the mTOR signaling pathway and make some predictions. Frontiers Media S.A. 2023-05-09 /pmc/articles/PMC10203478/ /pubmed/37228652 http://dx.doi.org/10.3389/fcell.2023.1186850 Text en Copyright © 2023 Ling, Xu, Qian, Xiang, Xuan and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ling, Bai
Xu, Yunyang
Qian, Siyuan
Xiang, Ze
Xuan, Shihai
Wu, Jian
Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway
title Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway
title_full Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway
title_fullStr Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway
title_full_unstemmed Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway
title_short Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway
title_sort regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mtor signaling pathway
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203478/
https://www.ncbi.nlm.nih.gov/pubmed/37228652
http://dx.doi.org/10.3389/fcell.2023.1186850
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