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Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances
Morusin is a natural product that has been isolated from the bark of Morus alba, a species of mulberry tree. It belongs to the flavonoid family of chemicals, which is abundantly present in the plant world and is recognized for its wide range of biological activities. Morusin has a number of biologic...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203489/ https://www.ncbi.nlm.nih.gov/pubmed/37228582 http://dx.doi.org/10.3389/fmolb.2023.1168298 |
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author | Hafeez, Amna Khan, Zeeshan Armaghan, Muhammad Khan, Khushbukhat Sönmez Gürer, Eda Abdull Razis, Ahmad Faizal Modu, Babagana Almarhoon, Zainab M. Setzer, William N. Sharifi-Rad, Javad |
author_facet | Hafeez, Amna Khan, Zeeshan Armaghan, Muhammad Khan, Khushbukhat Sönmez Gürer, Eda Abdull Razis, Ahmad Faizal Modu, Babagana Almarhoon, Zainab M. Setzer, William N. Sharifi-Rad, Javad |
author_sort | Hafeez, Amna |
collection | PubMed |
description | Morusin is a natural product that has been isolated from the bark of Morus alba, a species of mulberry tree. It belongs to the flavonoid family of chemicals, which is abundantly present in the plant world and is recognized for its wide range of biological activities. Morusin has a number of biological characteristics, including anti-inflammatory, anti-microbial, neuro-protective, and antioxidant capabilities. Morusin has exhibited anti-tumor properties in many different forms of cancer, including breast, prostate, gastric, hepatocarcinoma, glioblastoma, and pancreatic cancer. Potential of morusin as an alternative treatment method for resistant malignancies needs to be explored in animal models in order to move toward clinical trials. In the recent years several novel findings regarding the therapeutic potential of morusin have been made. This aim of this review is to provide an overview of the present understanding of morusin’s beneficial effects on human health as well as provide a comprehensive and up-to-date discussion of morusin’s anti-cancer properties with a special focus on in vitro and in vivo studies. This review will aid future research on the creation of polyphenolic medicines in the prenylflavone family, for the management and treatment of cancers. |
format | Online Article Text |
id | pubmed-10203489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102034892023-05-24 Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances Hafeez, Amna Khan, Zeeshan Armaghan, Muhammad Khan, Khushbukhat Sönmez Gürer, Eda Abdull Razis, Ahmad Faizal Modu, Babagana Almarhoon, Zainab M. Setzer, William N. Sharifi-Rad, Javad Front Mol Biosci Molecular Biosciences Morusin is a natural product that has been isolated from the bark of Morus alba, a species of mulberry tree. It belongs to the flavonoid family of chemicals, which is abundantly present in the plant world and is recognized for its wide range of biological activities. Morusin has a number of biological characteristics, including anti-inflammatory, anti-microbial, neuro-protective, and antioxidant capabilities. Morusin has exhibited anti-tumor properties in many different forms of cancer, including breast, prostate, gastric, hepatocarcinoma, glioblastoma, and pancreatic cancer. Potential of morusin as an alternative treatment method for resistant malignancies needs to be explored in animal models in order to move toward clinical trials. In the recent years several novel findings regarding the therapeutic potential of morusin have been made. This aim of this review is to provide an overview of the present understanding of morusin’s beneficial effects on human health as well as provide a comprehensive and up-to-date discussion of morusin’s anti-cancer properties with a special focus on in vitro and in vivo studies. This review will aid future research on the creation of polyphenolic medicines in the prenylflavone family, for the management and treatment of cancers. Frontiers Media S.A. 2023-05-09 /pmc/articles/PMC10203489/ /pubmed/37228582 http://dx.doi.org/10.3389/fmolb.2023.1168298 Text en Copyright © 2023 Hafeez, Khan, Armaghan, Khan, Sönmez Gürer, Abdull Razis, Modu, Almarhoon, Setzer and Sharifi-Rad. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Hafeez, Amna Khan, Zeeshan Armaghan, Muhammad Khan, Khushbukhat Sönmez Gürer, Eda Abdull Razis, Ahmad Faizal Modu, Babagana Almarhoon, Zainab M. Setzer, William N. Sharifi-Rad, Javad Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances |
title | Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances |
title_full | Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances |
title_fullStr | Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances |
title_full_unstemmed | Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances |
title_short | Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances |
title_sort | exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203489/ https://www.ncbi.nlm.nih.gov/pubmed/37228582 http://dx.doi.org/10.3389/fmolb.2023.1168298 |
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