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Preclinical investigations of the efficacy of the glutaminase inhibitor CB-839 alone and in combinations in chronic lymphocytic leukemia

INTRODUCTION: Chronic lymphocytic leukemia (CLL) cells are metabolically flexible and adapt to modern anticancer treatments. Bruton tyrosine kinase (BTK) and B-cell lymphoma-2 (BCL-2) inhibitors have been widely used to treat CLL, but CLL cells become resistant to these treatments over time. CB-839...

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Detalles Bibliográficos
Autores principales:	Timofeeva, Natalia, Ayres, Mary L., Baran, Natalia, Santiago-O’Farrill, Janice M., Bildik, Gamze, Lu, Zhen, Konopleva, Marina, Gandhi, Varsha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203524/ https://www.ncbi.nlm.nih.gov/pubmed/37228498 http://dx.doi.org/10.3389/fonc.2023.1161254

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