Macrophage Nrf 2 the rescue

The exuberant phagocytosis of apoptotic cell corpses by macrophages in Drosophila embryos creates highly oxidative environments. Stow and Sweet discuss work from Clemente and Weavers (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202203062) showing for the first time how macrophage Nrf2 is primed...

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Detalles Bibliográficos
Autores principales: Stow, Jennifer L., Sweet, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203544/
https://www.ncbi.nlm.nih.gov/pubmed/37213075
http://dx.doi.org/10.1083/jcb.202305036
Descripción
Sumario:The exuberant phagocytosis of apoptotic cell corpses by macrophages in Drosophila embryos creates highly oxidative environments. Stow and Sweet discuss work from Clemente and Weavers (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202203062) showing for the first time how macrophage Nrf2 is primed to help sustain immune function and mitigate bystander oxidative damage.

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