Selection of biophysically favorable antibody variants using a modified Flp-In CHO mammalian display platform

Mammalian display enables the selection of biophysically favorable antibodies from a large IgG antibody library displayed on the plasma membrane of mammalian cells. We constructed and validated a novel mammalian display platform utilizing the commercially available Flp-In CHO cell line as a starting...

Descripción completa

Detalles Bibliográficos
Autores principales: Huhtinen, Olli, Salbo, Rune, Lamminmäki, Urpo, Prince, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203562/
https://www.ncbi.nlm.nih.gov/pubmed/37229492
http://dx.doi.org/10.3389/fbioe.2023.1170081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203562/
https://www.ncbi.nlm.nih.gov/pubmed/37229492
http://dx.doi.org/10.3389/fbioe.2023.1170081

Ejemplares similares