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Substance P analogs devoid of key residues fail to activate human mast cells via MRGPRX2

Mast cells play an important role in disease pathogenesis by secreting immunomodulatory molecules. Mast cells are primarily activated by the crosslinking of their high affinity IgE receptors (FcεRI) by antigen bound immunoglobulin (Ig)E antibody complexes. However, mast cells can also be activated b...

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Detalles Bibliográficos
Autores principales:	Raj, Shammy, Hlushak, Stepan, Arizmendi, Narcy, Kovalenko, Andriy, Kulka, Marianna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203606/ https://www.ncbi.nlm.nih.gov/pubmed/37228611 http://dx.doi.org/10.3389/fimmu.2023.1155740

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