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The effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability

Repetitive electrical nerve stimulation can induce a long-lasting perturbation of the axon's membrane potential, resulting in unstable stimulus-response relationships. Despite being observed in electrophysiology, the precise mechanism underlying electrical stimulation-dependent (ES-dependent) i...

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Autores principales: Yu, Shoujun, Yue, Wenji, Guo, Tianruo, Liu, Yonghong, Zhang, Yapeng, Khademi, Sara, Zhou, Tian, Xu, Zhen, Song, Bing, Wu, Tianzhun, Liu, Fenglin, Tai, Yanlong, Yu, Xuefei, Wang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203711/
https://www.ncbi.nlm.nih.gov/pubmed/37229430
http://dx.doi.org/10.3389/fnins.2023.1178606
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author Yu, Shoujun
Yue, Wenji
Guo, Tianruo
Liu, Yonghong
Zhang, Yapeng
Khademi, Sara
Zhou, Tian
Xu, Zhen
Song, Bing
Wu, Tianzhun
Liu, Fenglin
Tai, Yanlong
Yu, Xuefei
Wang, Hao
author_facet Yu, Shoujun
Yue, Wenji
Guo, Tianruo
Liu, Yonghong
Zhang, Yapeng
Khademi, Sara
Zhou, Tian
Xu, Zhen
Song, Bing
Wu, Tianzhun
Liu, Fenglin
Tai, Yanlong
Yu, Xuefei
Wang, Hao
author_sort Yu, Shoujun
collection PubMed
description Repetitive electrical nerve stimulation can induce a long-lasting perturbation of the axon's membrane potential, resulting in unstable stimulus-response relationships. Despite being observed in electrophysiology, the precise mechanism underlying electrical stimulation-dependent (ES-dependent) instability is still an open question. This study proposes a model to reveal a facet of this problem: how threshold fluctuation affects electrical nerve stimulations. This study proposes a new method based on a Circuit-Probability theory (C-P theory) to reveal the interlinkages between the subthreshold oscillation induced by neurons' resonance and ES-dependent instability of neural response. Supported by in-vivo studies, this new model predicts several key characteristics of ES-dependent instability and proposes a stimulation method to minimize the instability. This model provides a powerful tool to improve our understanding of the interaction between the external electric field and the complexity of the biophysical characteristics of axons.
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spelling pubmed-102037112023-05-24 The effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability Yu, Shoujun Yue, Wenji Guo, Tianruo Liu, Yonghong Zhang, Yapeng Khademi, Sara Zhou, Tian Xu, Zhen Song, Bing Wu, Tianzhun Liu, Fenglin Tai, Yanlong Yu, Xuefei Wang, Hao Front Neurosci Neuroscience Repetitive electrical nerve stimulation can induce a long-lasting perturbation of the axon's membrane potential, resulting in unstable stimulus-response relationships. Despite being observed in electrophysiology, the precise mechanism underlying electrical stimulation-dependent (ES-dependent) instability is still an open question. This study proposes a model to reveal a facet of this problem: how threshold fluctuation affects electrical nerve stimulations. This study proposes a new method based on a Circuit-Probability theory (C-P theory) to reveal the interlinkages between the subthreshold oscillation induced by neurons' resonance and ES-dependent instability of neural response. Supported by in-vivo studies, this new model predicts several key characteristics of ES-dependent instability and proposes a stimulation method to minimize the instability. This model provides a powerful tool to improve our understanding of the interaction between the external electric field and the complexity of the biophysical characteristics of axons. Frontiers Media S.A. 2023-05-09 /pmc/articles/PMC10203711/ /pubmed/37229430 http://dx.doi.org/10.3389/fnins.2023.1178606 Text en Copyright © 2023 Yu, Yue, Guo, Liu, Zhang, Khademi, Zhou, Xu, Song, Wu, Liu, Tai, Yu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yu, Shoujun
Yue, Wenji
Guo, Tianruo
Liu, Yonghong
Zhang, Yapeng
Khademi, Sara
Zhou, Tian
Xu, Zhen
Song, Bing
Wu, Tianzhun
Liu, Fenglin
Tai, Yanlong
Yu, Xuefei
Wang, Hao
The effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability
title The effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability
title_full The effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability
title_fullStr The effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability
title_full_unstemmed The effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability
title_short The effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability
title_sort effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203711/
https://www.ncbi.nlm.nih.gov/pubmed/37229430
http://dx.doi.org/10.3389/fnins.2023.1178606
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