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Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients: A systematic review

BACKGROUND: Detection of circulating tumor-derived material (cTM) in the peripheral blood (PB) of cancer patients has been shown to be useful in early diagnosis, prediction of prognosis, and disease monitoring. However, it has not yet been thoroughly evaluated for pediatric sarcoma patients. METHODS...

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Autores principales: Kjær, Eva Kristine Ruud, Vase, Christian Bach, Rossing, Maria, Ahlborn, Lise Barlebo, Hjalgrim, Lisa Lyngsie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203770/
https://www.ncbi.nlm.nih.gov/pubmed/37201250
http://dx.doi.org/10.1016/j.tranon.2023.101690
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author Kjær, Eva Kristine Ruud
Vase, Christian Bach
Rossing, Maria
Ahlborn, Lise Barlebo
Hjalgrim, Lisa Lyngsie
author_facet Kjær, Eva Kristine Ruud
Vase, Christian Bach
Rossing, Maria
Ahlborn, Lise Barlebo
Hjalgrim, Lisa Lyngsie
author_sort Kjær, Eva Kristine Ruud
collection PubMed
description BACKGROUND: Detection of circulating tumor-derived material (cTM) in the peripheral blood (PB) of cancer patients has been shown to be useful in early diagnosis, prediction of prognosis, and disease monitoring. However, it has not yet been thoroughly evaluated for pediatric sarcoma patients. METHODS: We searched the PubMed and EMBASE databases for studies reporting the detection of circulating tumor cells, circulating tumor DNA, and circulating RNA in PB of pediatric sarcoma patients. Data on performance in identifying cTM and its applicability in diagnosis, and evaluation of tumor characteristics, prognostic factors, and treatment response was extracted from publications. RESULTS: A total of 79 studies were assigned for the present systematic review, including detection of circulating tumor cells (116 patients), circulating tumor DNA (716 patients), and circulating RNA (2887 patients). Circulating tumor cells were detected in 76% of patients. Circulating DNA was detected in 63% by targeted NGS, 66% by shallow WGS, and 79% by digital droplet PCR. Circulating RNA was detected in 37% of patients. CONCLUSION: Of the cTM from Ewing's sarcoma and rhabdomyosarcoma ctDNA proved to be the best target for clinical application including diagnosis, tumor characterization, prognosis, and monitoring of disease progression and treatment response. For osteosarcoma the most promising targets are copy number alterations or patient specific micro RNAs, however, further investigations are needed to obtain consensus on clinical utility.
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spelling pubmed-102037702023-05-24 Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients: A systematic review Kjær, Eva Kristine Ruud Vase, Christian Bach Rossing, Maria Ahlborn, Lise Barlebo Hjalgrim, Lisa Lyngsie Transl Oncol Commentary BACKGROUND: Detection of circulating tumor-derived material (cTM) in the peripheral blood (PB) of cancer patients has been shown to be useful in early diagnosis, prediction of prognosis, and disease monitoring. However, it has not yet been thoroughly evaluated for pediatric sarcoma patients. METHODS: We searched the PubMed and EMBASE databases for studies reporting the detection of circulating tumor cells, circulating tumor DNA, and circulating RNA in PB of pediatric sarcoma patients. Data on performance in identifying cTM and its applicability in diagnosis, and evaluation of tumor characteristics, prognostic factors, and treatment response was extracted from publications. RESULTS: A total of 79 studies were assigned for the present systematic review, including detection of circulating tumor cells (116 patients), circulating tumor DNA (716 patients), and circulating RNA (2887 patients). Circulating tumor cells were detected in 76% of patients. Circulating DNA was detected in 63% by targeted NGS, 66% by shallow WGS, and 79% by digital droplet PCR. Circulating RNA was detected in 37% of patients. CONCLUSION: Of the cTM from Ewing's sarcoma and rhabdomyosarcoma ctDNA proved to be the best target for clinical application including diagnosis, tumor characterization, prognosis, and monitoring of disease progression and treatment response. For osteosarcoma the most promising targets are copy number alterations or patient specific micro RNAs, however, further investigations are needed to obtain consensus on clinical utility. Neoplasia Press 2023-05-16 /pmc/articles/PMC10203770/ /pubmed/37201250 http://dx.doi.org/10.1016/j.tranon.2023.101690 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Commentary
Kjær, Eva Kristine Ruud
Vase, Christian Bach
Rossing, Maria
Ahlborn, Lise Barlebo
Hjalgrim, Lisa Lyngsie
Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients: A systematic review
title Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients: A systematic review
title_full Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients: A systematic review
title_fullStr Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients: A systematic review
title_full_unstemmed Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients: A systematic review
title_short Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients: A systematic review
title_sort detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients: a systematic review
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203770/
https://www.ncbi.nlm.nih.gov/pubmed/37201250
http://dx.doi.org/10.1016/j.tranon.2023.101690
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