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Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease

Dopamine replacement therapy (DRT) represents the standard treatment for Parkinson's disease (PD), however, instant and long‐term medication influence on patients' brain function have not been delineated. Here, a total of 97 drug‐naïve patients, 43 patients under long‐term DRT, and 94 norm...

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Autores principales: Wu, Chenqing, Wu, Haoting, Zhou, Cheng, Guan, Xiaojun, Guo, Tao, Cao, Zhengye, Wu, Jingjing, Liu, Xiaocao, Chen, Jingwen, Wen, Jiaqi, Qin, Jianmei, Tan, Sijia, Duanmu, Xiaojie, Zhang, Baorong, Huang, Peiyu, Xu, Xiaojun, Zhang, Minming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203796/
https://www.ncbi.nlm.nih.gov/pubmed/37126590
http://dx.doi.org/10.1002/hbm.26316
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author Wu, Chenqing
Wu, Haoting
Zhou, Cheng
Guan, Xiaojun
Guo, Tao
Cao, Zhengye
Wu, Jingjing
Liu, Xiaocao
Chen, Jingwen
Wen, Jiaqi
Qin, Jianmei
Tan, Sijia
Duanmu, Xiaojie
Zhang, Baorong
Huang, Peiyu
Xu, Xiaojun
Zhang, Minming
author_facet Wu, Chenqing
Wu, Haoting
Zhou, Cheng
Guan, Xiaojun
Guo, Tao
Cao, Zhengye
Wu, Jingjing
Liu, Xiaocao
Chen, Jingwen
Wen, Jiaqi
Qin, Jianmei
Tan, Sijia
Duanmu, Xiaojie
Zhang, Baorong
Huang, Peiyu
Xu, Xiaojun
Zhang, Minming
author_sort Wu, Chenqing
collection PubMed
description Dopamine replacement therapy (DRT) represents the standard treatment for Parkinson's disease (PD), however, instant and long‐term medication influence on patients' brain function have not been delineated. Here, a total of 97 drug‐naïve patients, 43 patients under long‐term DRT, and 94 normal control (NC) were, retrospectively, enrolled. Resting‐state functional magnetic resonance imaging data and motor symptom assessments were conducted before and after levodopa challenge test. Whole‐brain functional connectivity (FC) matrices were constructed. Network‐based statistics were performed to assess FC difference between drug‐naïve patients and NC, and these significant FCs were defined as disease‐related connectomes, which were used for further statistical analyses. Patients showed better motor performances after both long‐term DRT and levodopa challenge test. Two disease‐related connectomes were observed with distinct patterns. The FC of the increased connectome, which mainly consisted of the motor, visual, subcortical, and cerebellum networks, was higher in drug‐naïve patients than that in NC and was normalized after long‐term DRT (p‐value <.050). The decreased connectome was mainly composed of the motor, medial frontal, and salience networks and showed significantly lower FC in all patients than NC (p‐value <.050). The global FC of both increased and decreased connectome was significantly enhanced after levodopa challenge test (q‐value <0.050, false discovery rate‐corrected). The global FC of increased connectome in ON‐state was negatively associated with levodopa equivalency dose (r = −.496, q‐value = 0.007). Higher global FC of the decreased connectome was related to better motor performances (r = −.310, q‐value = 0.022). Our findings provided insights into brain functional alterations under dopaminergic medication and its benefit on motor symptoms.
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spelling pubmed-102037962023-05-24 Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease Wu, Chenqing Wu, Haoting Zhou, Cheng Guan, Xiaojun Guo, Tao Cao, Zhengye Wu, Jingjing Liu, Xiaocao Chen, Jingwen Wen, Jiaqi Qin, Jianmei Tan, Sijia Duanmu, Xiaojie Zhang, Baorong Huang, Peiyu Xu, Xiaojun Zhang, Minming Hum Brain Mapp Research Articles Dopamine replacement therapy (DRT) represents the standard treatment for Parkinson's disease (PD), however, instant and long‐term medication influence on patients' brain function have not been delineated. Here, a total of 97 drug‐naïve patients, 43 patients under long‐term DRT, and 94 normal control (NC) were, retrospectively, enrolled. Resting‐state functional magnetic resonance imaging data and motor symptom assessments were conducted before and after levodopa challenge test. Whole‐brain functional connectivity (FC) matrices were constructed. Network‐based statistics were performed to assess FC difference between drug‐naïve patients and NC, and these significant FCs were defined as disease‐related connectomes, which were used for further statistical analyses. Patients showed better motor performances after both long‐term DRT and levodopa challenge test. Two disease‐related connectomes were observed with distinct patterns. The FC of the increased connectome, which mainly consisted of the motor, visual, subcortical, and cerebellum networks, was higher in drug‐naïve patients than that in NC and was normalized after long‐term DRT (p‐value <.050). The decreased connectome was mainly composed of the motor, medial frontal, and salience networks and showed significantly lower FC in all patients than NC (p‐value <.050). The global FC of both increased and decreased connectome was significantly enhanced after levodopa challenge test (q‐value <0.050, false discovery rate‐corrected). The global FC of increased connectome in ON‐state was negatively associated with levodopa equivalency dose (r = −.496, q‐value = 0.007). Higher global FC of the decreased connectome was related to better motor performances (r = −.310, q‐value = 0.022). Our findings provided insights into brain functional alterations under dopaminergic medication and its benefit on motor symptoms. John Wiley & Sons, Inc. 2023-05-01 /pmc/articles/PMC10203796/ /pubmed/37126590 http://dx.doi.org/10.1002/hbm.26316 Text en © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Wu, Chenqing
Wu, Haoting
Zhou, Cheng
Guan, Xiaojun
Guo, Tao
Cao, Zhengye
Wu, Jingjing
Liu, Xiaocao
Chen, Jingwen
Wen, Jiaqi
Qin, Jianmei
Tan, Sijia
Duanmu, Xiaojie
Zhang, Baorong
Huang, Peiyu
Xu, Xiaojun
Zhang, Minming
Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease
title Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease
title_full Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease
title_fullStr Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease
title_full_unstemmed Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease
title_short Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease
title_sort normalization effect of dopamine replacement therapy on brain functional connectome in parkinson's disease
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203796/
https://www.ncbi.nlm.nih.gov/pubmed/37126590
http://dx.doi.org/10.1002/hbm.26316
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