StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival

The pathological accumulation of cholesterol is a signature feature of Niemann–Pick type C (NPC) disease, in which excessive lipid levels induce Purkinje cell death in the cerebellum. NPC1 encodes a lysosomal cholesterol-binding protein, and mutations in NPC1 drive cholesterol accumulation in late e...

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Detalles Bibliográficos
Autores principales: Sterling, Felicity R., D'Amico, Jon, Brumfield, Alexandria M., Huegel, Kara L., Vaughan, Patricia S., Morris, Kathryn, Schwarz, Shelby, Joyce, Michelle V., Boggess, Bill, Champion, Matthew M., Maciuba, Kevin, Allen, Philip, Marasco, Eric, Koch, Grant, Gonzalez, Peter, Hodges, Shannon, Leahy, Shannon, Gerstbauer, Erica, Hinchcliffe, Edward H., Vaughan, Kevin T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203878/
https://www.ncbi.nlm.nih.gov/pubmed/36861884
http://dx.doi.org/10.1242/jcs.260662

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