Haldol Targets IQGAP1 Pathway and Promotes Novel Partner Interactions in Glioblastoma Cell Lines

Glioblastoma multiform (GBM) is an incurable heterogenous brain cancer with few clinical target options. IQGAP1 is a scaffold oncoprotein involved in GBM with unclear mechanism. Here we report that the antipsychotic drug Haldol differentially alters IQGAP1 signaling and inhibits GBM cell proliferati...

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Detalles Bibliográficos
Autores principales: Iyer, Varun J., Osman, Mahasin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203884/
https://www.ncbi.nlm.nih.gov/pubmed/37228393
http://dx.doi.org/10.17912/micropub.biology.000822
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author Iyer, Varun J.
Osman, Mahasin A.
author_facet Iyer, Varun J.
Osman, Mahasin A.
author_sort Iyer, Varun J.
collection PubMed
description Glioblastoma multiform (GBM) is an incurable heterogenous brain cancer with few clinical target options. IQGAP1 is a scaffold oncoprotein involved in GBM with unclear mechanism. Here we report that the antipsychotic drug Haldol differentially alters IQGAP1 signaling and inhibits GBM cell proliferation, thus providing novel molecular signatures for GBM classification and potential targeted therapy in personalized medicine.
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spelling pubmed-102038842023-05-24 Haldol Targets IQGAP1 Pathway and Promotes Novel Partner Interactions in Glioblastoma Cell Lines Iyer, Varun J. Osman, Mahasin A. MicroPubl Biol New Finding Glioblastoma multiform (GBM) is an incurable heterogenous brain cancer with few clinical target options. IQGAP1 is a scaffold oncoprotein involved in GBM with unclear mechanism. Here we report that the antipsychotic drug Haldol differentially alters IQGAP1 signaling and inhibits GBM cell proliferation, thus providing novel molecular signatures for GBM classification and potential targeted therapy in personalized medicine. Caltech Library 2023-05-08 /pmc/articles/PMC10203884/ /pubmed/37228393 http://dx.doi.org/10.17912/micropub.biology.000822 Text en Copyright: © 2023 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Iyer, Varun J.
Osman, Mahasin A.
Haldol Targets IQGAP1 Pathway and Promotes Novel Partner Interactions in Glioblastoma Cell Lines
title Haldol Targets IQGAP1 Pathway and Promotes Novel Partner Interactions in Glioblastoma Cell Lines
title_full Haldol Targets IQGAP1 Pathway and Promotes Novel Partner Interactions in Glioblastoma Cell Lines
title_fullStr Haldol Targets IQGAP1 Pathway and Promotes Novel Partner Interactions in Glioblastoma Cell Lines
title_full_unstemmed Haldol Targets IQGAP1 Pathway and Promotes Novel Partner Interactions in Glioblastoma Cell Lines
title_short Haldol Targets IQGAP1 Pathway and Promotes Novel Partner Interactions in Glioblastoma Cell Lines
title_sort haldol targets iqgap1 pathway and promotes novel partner interactions in glioblastoma cell lines
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203884/
https://www.ncbi.nlm.nih.gov/pubmed/37228393
http://dx.doi.org/10.17912/micropub.biology.000822
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AT osmanmahasina haldoltargetsiqgap1pathwayandpromotesnovelpartnerinteractionsinglioblastomacelllines

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