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The Efficiency of Metabolic Labeling of DNA by Diels–Alder Reactions with Inverse Electron Demand: Correlation with the Size of Modified 2′-Deoxyuridines
[Image: see text] A selection of four different 2′-deoxyuridines with three different dienophiles of different sizes was synthesized. Their inverse electron demand Diels–Alder reactivity increases from k(2) = 0.15 × 10(–2) M(–1) s(–1) to k(2) = 105 × 10(–2) M(–1) s(–1) with increasing ring strain of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204056/ https://www.ncbi.nlm.nih.gov/pubmed/36921617 http://dx.doi.org/10.1021/acschembio.3c00079 |