COVID-19 infected ST-Elevation myocardial infarction in India (COSTA INDIA)

OBJECTIVE: To find out differences in the presentation, management and outcomes of COVID-19 infected STEMI patients compared to age and sex-matched non-infected STEMI patients treated during the same period. METHODS: This was a retrospective multicentre observational registry in which we collected d...

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Detalles Bibliográficos
Autores principales: Jabir, Abdullakutty, Geevar Zachariah, Mohanan, Padinhare Purayil, Gupta, Mohit Dayal, Ramakrishnan, Sivasubramanian, Meena, Chandra Bhan, Sridhar, L., Girish, Meennahalli Palleda, Das, Dipak Ranjan, Gupta, Anshul, Praveen Nagula, Tom Devasia, Bhavesh Vajifdar, Kamlesh Thakkar, Urmil Shah, Tanuj Bhatia, Smit Srivastava, Sanjeev Sharma, Priya Kubendiran, Jayagopal, Pathiyil Balagopalan, Sudeep Kumar, Deepthy Sadanandan, Lincy Mathew, Nitish Naik, Anup Banerji, Ashraf, S.M., Asokan, P.K., Bharti, Bishwa Bhushan, Majumder, Biswajit, Dhiman Kahali, Sinha, Dhurjati Prasad, Sharma, Dipak, Dastidar, Dipankar Ghosh, Dipankar Mukhapdhyay, Wander, Gurpreet Sing, Bali, Harinder Kumar, Kesavamoorthy, B., Agarwala, Manoj Kumar, Khanna, Narendra Nath, Natesh, B.H., Goel, Pravin K., Chakraborty, Rabindra Nath, Jain, Rajendra Kumar, Rakesh Yadav, Sameer Dani, L., Satyavan Sharma, Satyendra Tewari, Sethi, K.K., Sharad Chandra, Mandal, Subrato, Bhandari, Suman, Sikdar, Sundandan, Vivek Gupta, Rath, Pratap Chandra, Bang, Vijay Harikisan, Debabrata Roy, Das, Mrinal Kanti, Banerjee, Partho Sarathi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204278/
https://www.ncbi.nlm.nih.gov/pubmed/37230465
http://dx.doi.org/10.1016/j.ihj.2023.05.009
Descripción
Sumario:OBJECTIVE: To find out differences in the presentation, management and outcomes of COVID-19 infected STEMI patients compared to age and sex-matched non-infected STEMI patients treated during the same period. METHODS: This was a retrospective multicentre observational registry in which we collected data of COVID-19 positive STEMI patients from selected tertiary care hospitals across India. For every COVID-19 positive STEMI patient, two age and sex-matched COVID-19 negative STEMI patients were enrolled as control. The primary endpoint was a composite of in-hospital mortality, re-infarction, heart failure, and stroke. RESULTS: 410 COVID-19 positive STEMI cases were compared with 799 COVID-19 negative STEMI cases. The composite of death/reinfarction/stroke/heart failure was significantly higher among the COVID-19 positive STEMI patients compared with COVID-19 negative STEMI cases (27.1% vs 20.7% p value = 0.01); though mortality rate did not differ significantly (8.0% vs 5.8% p value = 0.13). Significantly lower proportion of COVID-19 positive STEMI patients received reperfusion treatment and primary PCI (60.7% vs 71.1% p value=< 0.001 and 15.4% vs 23.4% p value = 0.001 respectively). Rate of systematic early PCI (pharmaco-invasive treatment) was significantly lower in the COVID-19 positive group compared with COVID-19 negative group. There was no difference in the prevalence of high thrombus burden (14.5% and 12.0% p value = 0.55 among COVID-19 positive and negative patients respectively) CONCLUSIONS: In this large registry of STEMI patients, we did not find significant excess in in-hospital mortality among COVID-19 co-infected patients compared with non-infected patients despite lower rate of primary PCI and reperfusion treatment, though composite of in-hospital mortality, re-infarction, stroke and heart failure was higher.

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