Cargando…
Elevated NT-proBNP predicts unfavorable outcomes in patients with acute ischemic stroke after thrombolytic therapy
OBJECTIVE: Few studies correlated n-terminal pro-brain natriuretic peptide (NT-proBNP) with early neurological deterioration (END) and prognosis of acute ischaemic stroke (AIS) patients with rt-PA intravenous thrombolysis. Therefore this study aimed to investigate the relationship between NT-proBNP...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204306/ https://www.ncbi.nlm.nih.gov/pubmed/37221489 http://dx.doi.org/10.1186/s12883-023-03222-6 |
_version_ | 1785045805521960960 |
---|---|
author | Zhu, Zhuang Muhammad, Bilal Du, Bo Gu, Ning Meng, Tian-Yue Kan, Shu Mu, Ying-Feng Cheng, Yan-Bo Zhu, Shi-Guang Geng, De-Qin |
author_facet | Zhu, Zhuang Muhammad, Bilal Du, Bo Gu, Ning Meng, Tian-Yue Kan, Shu Mu, Ying-Feng Cheng, Yan-Bo Zhu, Shi-Guang Geng, De-Qin |
author_sort | Zhu, Zhuang |
collection | PubMed |
description | OBJECTIVE: Few studies correlated n-terminal pro-brain natriuretic peptide (NT-proBNP) with early neurological deterioration (END) and prognosis of acute ischaemic stroke (AIS) patients with rt-PA intravenous thrombolysis. Therefore this study aimed to investigate the relationship between NT-proBNP and END, and prognosis after intravenous thrombolysis in patients with AIS. METHODS: A total of 325 patients with AIS were enrolled. We performed the natural logarithm transformation on the NT-proBNP [ln(NT-proBNP)]. Univariate and multivariate logistic regression analyses were performed to assess the relationship between ln(NT-proBNP) and END, and prognosis and receiver operating characteristic (ROC) curves were used to show the sensitivity and specificity of NT-proBNP. RESULTS: After thrombolysis, among 325 patients with AIS, 43 patients (13.2%) developed END. In addition, three months follow-up showed a poor prognosis in 98 cases (30.2%) and a good prognosis in 227 cases (69.8%). Multivariate logistic regression analysis showed that ln(NT-proBNP) was an independent risk factor for END (OR = 1.450,95%CI:1.072 ~ 1.963, P = 0.016) and poor prognosis at three months follow-up (OR = 1.767, 95%CI: 1.347 ~ 2.317, P < 0.001) respectively. According to ROC curve analysis, ln(NT-proBNP) (AUC 0.735, 95%CI: 0.674 ~0.796, P < 0.001) had a good predictive value for poor prognosis, with a predictive value of 5.12 and sensitivity and specificity of 79.59% and 60.35% respectively. When combined with NIHSS to predict END(AUC 0.718, 95%CI: 0.631 ~ 0.805, P < 0.001) and poor prognosis(AUC 0.780, 95%CI: 0.724 ~ 0.836, P < 0.001), the predictive value of the model is further improved. CONCLUSION: NT-proBNP is independently associated with END and poor prognosis in patients with AIS following intravenous thrombolysis and has a particular predictive value for END and poor prognosis. |
format | Online Article Text |
id | pubmed-10204306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102043062023-05-24 Elevated NT-proBNP predicts unfavorable outcomes in patients with acute ischemic stroke after thrombolytic therapy Zhu, Zhuang Muhammad, Bilal Du, Bo Gu, Ning Meng, Tian-Yue Kan, Shu Mu, Ying-Feng Cheng, Yan-Bo Zhu, Shi-Guang Geng, De-Qin BMC Neurol Research OBJECTIVE: Few studies correlated n-terminal pro-brain natriuretic peptide (NT-proBNP) with early neurological deterioration (END) and prognosis of acute ischaemic stroke (AIS) patients with rt-PA intravenous thrombolysis. Therefore this study aimed to investigate the relationship between NT-proBNP and END, and prognosis after intravenous thrombolysis in patients with AIS. METHODS: A total of 325 patients with AIS were enrolled. We performed the natural logarithm transformation on the NT-proBNP [ln(NT-proBNP)]. Univariate and multivariate logistic regression analyses were performed to assess the relationship between ln(NT-proBNP) and END, and prognosis and receiver operating characteristic (ROC) curves were used to show the sensitivity and specificity of NT-proBNP. RESULTS: After thrombolysis, among 325 patients with AIS, 43 patients (13.2%) developed END. In addition, three months follow-up showed a poor prognosis in 98 cases (30.2%) and a good prognosis in 227 cases (69.8%). Multivariate logistic regression analysis showed that ln(NT-proBNP) was an independent risk factor for END (OR = 1.450,95%CI:1.072 ~ 1.963, P = 0.016) and poor prognosis at three months follow-up (OR = 1.767, 95%CI: 1.347 ~ 2.317, P < 0.001) respectively. According to ROC curve analysis, ln(NT-proBNP) (AUC 0.735, 95%CI: 0.674 ~0.796, P < 0.001) had a good predictive value for poor prognosis, with a predictive value of 5.12 and sensitivity and specificity of 79.59% and 60.35% respectively. When combined with NIHSS to predict END(AUC 0.718, 95%CI: 0.631 ~ 0.805, P < 0.001) and poor prognosis(AUC 0.780, 95%CI: 0.724 ~ 0.836, P < 0.001), the predictive value of the model is further improved. CONCLUSION: NT-proBNP is independently associated with END and poor prognosis in patients with AIS following intravenous thrombolysis and has a particular predictive value for END and poor prognosis. BioMed Central 2023-05-23 /pmc/articles/PMC10204306/ /pubmed/37221489 http://dx.doi.org/10.1186/s12883-023-03222-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhu, Zhuang Muhammad, Bilal Du, Bo Gu, Ning Meng, Tian-Yue Kan, Shu Mu, Ying-Feng Cheng, Yan-Bo Zhu, Shi-Guang Geng, De-Qin Elevated NT-proBNP predicts unfavorable outcomes in patients with acute ischemic stroke after thrombolytic therapy |
title | Elevated NT-proBNP predicts unfavorable outcomes in patients with acute ischemic stroke after thrombolytic therapy |
title_full | Elevated NT-proBNP predicts unfavorable outcomes in patients with acute ischemic stroke after thrombolytic therapy |
title_fullStr | Elevated NT-proBNP predicts unfavorable outcomes in patients with acute ischemic stroke after thrombolytic therapy |
title_full_unstemmed | Elevated NT-proBNP predicts unfavorable outcomes in patients with acute ischemic stroke after thrombolytic therapy |
title_short | Elevated NT-proBNP predicts unfavorable outcomes in patients with acute ischemic stroke after thrombolytic therapy |
title_sort | elevated nt-probnp predicts unfavorable outcomes in patients with acute ischemic stroke after thrombolytic therapy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204306/ https://www.ncbi.nlm.nih.gov/pubmed/37221489 http://dx.doi.org/10.1186/s12883-023-03222-6 |
work_keys_str_mv | AT zhuzhuang elevatedntprobnppredictsunfavorableoutcomesinpatientswithacuteischemicstrokeafterthrombolytictherapy AT muhammadbilal elevatedntprobnppredictsunfavorableoutcomesinpatientswithacuteischemicstrokeafterthrombolytictherapy AT dubo elevatedntprobnppredictsunfavorableoutcomesinpatientswithacuteischemicstrokeafterthrombolytictherapy AT guning elevatedntprobnppredictsunfavorableoutcomesinpatientswithacuteischemicstrokeafterthrombolytictherapy AT mengtianyue elevatedntprobnppredictsunfavorableoutcomesinpatientswithacuteischemicstrokeafterthrombolytictherapy AT kanshu elevatedntprobnppredictsunfavorableoutcomesinpatientswithacuteischemicstrokeafterthrombolytictherapy AT muyingfeng elevatedntprobnppredictsunfavorableoutcomesinpatientswithacuteischemicstrokeafterthrombolytictherapy AT chengyanbo elevatedntprobnppredictsunfavorableoutcomesinpatientswithacuteischemicstrokeafterthrombolytictherapy AT zhushiguang elevatedntprobnppredictsunfavorableoutcomesinpatientswithacuteischemicstrokeafterthrombolytictherapy AT gengdeqin elevatedntprobnppredictsunfavorableoutcomesinpatientswithacuteischemicstrokeafterthrombolytictherapy |