Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CL(pro) inhibitors against SARS-CoV-2

A series of peptidomimetic compounds containing benzothiazolyl ketone and [2.2.1] azabicyclic ring was designed, synthesized and evaluated in the hope of obtaining potent oral 3CL(pro) inhibitors with improved pharmacokinetic properties. Among the target compounds, 11b had the best enzymatic potency...

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Detalles Bibliográficos
Autores principales: Yang, Hanxi, You, Mengyuan, Shu, Xiaoyang, Zhen, Jingyao, Zhu, Mengwei, Fu, Tiantian, Zhang, Yan, Jiang, Xiangrui, Zhang, Leike, Xu, Yechun, Zhang, Yumin, Su, Haixia, Zhang, Qiumeng, Shen, Jingshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204345/
https://www.ncbi.nlm.nih.gov/pubmed/37253309
http://dx.doi.org/10.1016/j.ejmech.2023.115512

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