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Extension of Lung Damage at Chest Computed Tomography in Severely Ill COVID-19 Patients Treated with Interleukin-6 Receptor Blockers Correlates with Inflammatory Cytokines Production and Prognosis

Elevated inflammatory markers are associated with severe coronavirus disease 2019 (COVID-19), and some patients benefit from Interleukin (IL)-6 pathway inhibitors. Different chest computed tomography (CT) scoring systems have shown a prognostic value in COVID-19, but not specifically in anti-IL-6-tr...

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Autores principales: Calandriello, Lucio, De Lorenzis, Enrico, Cicchetti, Giuseppe, D’Abronzo, Rosa, Infante, Amato, Castaldo, Federico, Del Ciello, Annemilia, Farchione, Alessandra, Gremese, Elisa, Marano, Riccardo, Natale, Luigi, D’Agostino, Maria Antonietta, Bosello, Silvia Laura, Larici, Anna Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204376/
https://www.ncbi.nlm.nih.gov/pubmed/37218940
http://dx.doi.org/10.3390/tomography9030080
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author Calandriello, Lucio
De Lorenzis, Enrico
Cicchetti, Giuseppe
D’Abronzo, Rosa
Infante, Amato
Castaldo, Federico
Del Ciello, Annemilia
Farchione, Alessandra
Gremese, Elisa
Marano, Riccardo
Natale, Luigi
D’Agostino, Maria Antonietta
Bosello, Silvia Laura
Larici, Anna Rita
author_facet Calandriello, Lucio
De Lorenzis, Enrico
Cicchetti, Giuseppe
D’Abronzo, Rosa
Infante, Amato
Castaldo, Federico
Del Ciello, Annemilia
Farchione, Alessandra
Gremese, Elisa
Marano, Riccardo
Natale, Luigi
D’Agostino, Maria Antonietta
Bosello, Silvia Laura
Larici, Anna Rita
author_sort Calandriello, Lucio
collection PubMed
description Elevated inflammatory markers are associated with severe coronavirus disease 2019 (COVID-19), and some patients benefit from Interleukin (IL)-6 pathway inhibitors. Different chest computed tomography (CT) scoring systems have shown a prognostic value in COVID-19, but not specifically in anti-IL-6-treated patients at high risk of respiratory failure. We aimed to explore the relationship between baseline CT findings and inflammatory conditions and to evaluate the prognostic value of chest CT scores and laboratory findings in COVID-19 patients specifically treated with anti-IL-6. Baseline CT lung involvement was assessed in 51 hospitalized COVID-19 patients naive to glucocorticoids and other immunosuppressants using four CT scoring systems. CT data were correlated with systemic inflammation and 30-day prognosis after anti-IL-6 treatment. All the considered CT scores showed a negative correlation with pulmonary function and a positive one with C-reactive protein (CRP), IL-6, IL-8, and Tumor Necrosis Factor α (TNF-α) serum levels. All the performed scores were prognostic factors, but the disease extension assessed by the six-lung-zone CT score (S24) was the only independently associated with intensive care unit (ICU) admission (p = 0.04). In conclusion, CT involvement correlates with laboratory inflammation markers and is an independent prognostic factor in COVID-19 patients representing a further tool to implement prognostic stratification in hospitalized patients.
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spelling pubmed-102043762023-05-24 Extension of Lung Damage at Chest Computed Tomography in Severely Ill COVID-19 Patients Treated with Interleukin-6 Receptor Blockers Correlates with Inflammatory Cytokines Production and Prognosis Calandriello, Lucio De Lorenzis, Enrico Cicchetti, Giuseppe D’Abronzo, Rosa Infante, Amato Castaldo, Federico Del Ciello, Annemilia Farchione, Alessandra Gremese, Elisa Marano, Riccardo Natale, Luigi D’Agostino, Maria Antonietta Bosello, Silvia Laura Larici, Anna Rita Tomography Article Elevated inflammatory markers are associated with severe coronavirus disease 2019 (COVID-19), and some patients benefit from Interleukin (IL)-6 pathway inhibitors. Different chest computed tomography (CT) scoring systems have shown a prognostic value in COVID-19, but not specifically in anti-IL-6-treated patients at high risk of respiratory failure. We aimed to explore the relationship between baseline CT findings and inflammatory conditions and to evaluate the prognostic value of chest CT scores and laboratory findings in COVID-19 patients specifically treated with anti-IL-6. Baseline CT lung involvement was assessed in 51 hospitalized COVID-19 patients naive to glucocorticoids and other immunosuppressants using four CT scoring systems. CT data were correlated with systemic inflammation and 30-day prognosis after anti-IL-6 treatment. All the considered CT scores showed a negative correlation with pulmonary function and a positive one with C-reactive protein (CRP), IL-6, IL-8, and Tumor Necrosis Factor α (TNF-α) serum levels. All the performed scores were prognostic factors, but the disease extension assessed by the six-lung-zone CT score (S24) was the only independently associated with intensive care unit (ICU) admission (p = 0.04). In conclusion, CT involvement correlates with laboratory inflammation markers and is an independent prognostic factor in COVID-19 patients representing a further tool to implement prognostic stratification in hospitalized patients. MDPI 2023-05-11 /pmc/articles/PMC10204376/ /pubmed/37218940 http://dx.doi.org/10.3390/tomography9030080 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Calandriello, Lucio
De Lorenzis, Enrico
Cicchetti, Giuseppe
D’Abronzo, Rosa
Infante, Amato
Castaldo, Federico
Del Ciello, Annemilia
Farchione, Alessandra
Gremese, Elisa
Marano, Riccardo
Natale, Luigi
D’Agostino, Maria Antonietta
Bosello, Silvia Laura
Larici, Anna Rita
Extension of Lung Damage at Chest Computed Tomography in Severely Ill COVID-19 Patients Treated with Interleukin-6 Receptor Blockers Correlates with Inflammatory Cytokines Production and Prognosis
title Extension of Lung Damage at Chest Computed Tomography in Severely Ill COVID-19 Patients Treated with Interleukin-6 Receptor Blockers Correlates with Inflammatory Cytokines Production and Prognosis
title_full Extension of Lung Damage at Chest Computed Tomography in Severely Ill COVID-19 Patients Treated with Interleukin-6 Receptor Blockers Correlates with Inflammatory Cytokines Production and Prognosis
title_fullStr Extension of Lung Damage at Chest Computed Tomography in Severely Ill COVID-19 Patients Treated with Interleukin-6 Receptor Blockers Correlates with Inflammatory Cytokines Production and Prognosis
title_full_unstemmed Extension of Lung Damage at Chest Computed Tomography in Severely Ill COVID-19 Patients Treated with Interleukin-6 Receptor Blockers Correlates with Inflammatory Cytokines Production and Prognosis
title_short Extension of Lung Damage at Chest Computed Tomography in Severely Ill COVID-19 Patients Treated with Interleukin-6 Receptor Blockers Correlates with Inflammatory Cytokines Production and Prognosis
title_sort extension of lung damage at chest computed tomography in severely ill covid-19 patients treated with interleukin-6 receptor blockers correlates with inflammatory cytokines production and prognosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204376/
https://www.ncbi.nlm.nih.gov/pubmed/37218940
http://dx.doi.org/10.3390/tomography9030080
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