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Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature

Metaplastic carcinoma of the breast (MpBC) is a very rare and aggressive type of breast cancer. Data focusing on MpBC are limited. The aim of this study was to describe the clinicopathological features of MpBC and evaluate the prognosis of patients with MpBC. Eligible articles about MpBC were identi...

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Autores principales: Papatheodoridi, Alkistis, Papamattheou, Eleni, Marinopoulos, Spyridon, Ntanasis-Stathopoulos, Ioannis, Dimitrakakis, Constantine, Giannos, Aris, Kaparelou, Maria, Liontos, Michalis, Dimopoulos, Meletios-Athanasios, Zagouri, Flora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204473/
https://www.ncbi.nlm.nih.gov/pubmed/37218987
http://dx.doi.org/10.3390/medsci11020035
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author Papatheodoridi, Alkistis
Papamattheou, Eleni
Marinopoulos, Spyridon
Ntanasis-Stathopoulos, Ioannis
Dimitrakakis, Constantine
Giannos, Aris
Kaparelou, Maria
Liontos, Michalis
Dimopoulos, Meletios-Athanasios
Zagouri, Flora
author_facet Papatheodoridi, Alkistis
Papamattheou, Eleni
Marinopoulos, Spyridon
Ntanasis-Stathopoulos, Ioannis
Dimitrakakis, Constantine
Giannos, Aris
Kaparelou, Maria
Liontos, Michalis
Dimopoulos, Meletios-Athanasios
Zagouri, Flora
author_sort Papatheodoridi, Alkistis
collection PubMed
description Metaplastic carcinoma of the breast (MpBC) is a very rare and aggressive type of breast cancer. Data focusing on MpBC are limited. The aim of this study was to describe the clinicopathological features of MpBC and evaluate the prognosis of patients with MpBC. Eligible articles about MpBC were identified by searching CASES SERIES gov and the MEDLINE bibliographic database for the period of 1 January 2010 to 1 June 2021 with the keywords metaplastic breast cancer, mammary gland cancer, neoplasm, tumor, and metaplastic carcinoma. In this study, we also report 46 cases of MpBC stemming from our hospital. Survival rates, clinical behavior, and pathological characteristics were analyzed. Data from 205 patients were included for analysis. The mean age at diagnosis was 55 (14.7) years. The TNM stage at diagnosis was mostly stage II (58.5%) and most tumors were triple negative. The median overall survival was 66 (12–118) months, and the median disease-free survival was 56.8 (11–102) months. Multivariate Cox regression analysis revealed that surgical treatment was associated with decreased risk of death (hazard ratio 0.11, 95% confidence interval 0.02–0.54, p = 0.01) while advanced TNM stage was associated with increased risk of death (hazard ratio 1.5, 95% confidence interval 1.04–2.28, p = 0.03). Our results revealed that surgical treatment and TNM stage were the only independent risk factors related to patients’ overall survival.
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spelling pubmed-102044732023-05-24 Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature Papatheodoridi, Alkistis Papamattheou, Eleni Marinopoulos, Spyridon Ntanasis-Stathopoulos, Ioannis Dimitrakakis, Constantine Giannos, Aris Kaparelou, Maria Liontos, Michalis Dimopoulos, Meletios-Athanasios Zagouri, Flora Med Sci (Basel) Review Metaplastic carcinoma of the breast (MpBC) is a very rare and aggressive type of breast cancer. Data focusing on MpBC are limited. The aim of this study was to describe the clinicopathological features of MpBC and evaluate the prognosis of patients with MpBC. Eligible articles about MpBC were identified by searching CASES SERIES gov and the MEDLINE bibliographic database for the period of 1 January 2010 to 1 June 2021 with the keywords metaplastic breast cancer, mammary gland cancer, neoplasm, tumor, and metaplastic carcinoma. In this study, we also report 46 cases of MpBC stemming from our hospital. Survival rates, clinical behavior, and pathological characteristics were analyzed. Data from 205 patients were included for analysis. The mean age at diagnosis was 55 (14.7) years. The TNM stage at diagnosis was mostly stage II (58.5%) and most tumors were triple negative. The median overall survival was 66 (12–118) months, and the median disease-free survival was 56.8 (11–102) months. Multivariate Cox regression analysis revealed that surgical treatment was associated with decreased risk of death (hazard ratio 0.11, 95% confidence interval 0.02–0.54, p = 0.01) while advanced TNM stage was associated with increased risk of death (hazard ratio 1.5, 95% confidence interval 1.04–2.28, p = 0.03). Our results revealed that surgical treatment and TNM stage were the only independent risk factors related to patients’ overall survival. MDPI 2023-05-19 /pmc/articles/PMC10204473/ /pubmed/37218987 http://dx.doi.org/10.3390/medsci11020035 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Papatheodoridi, Alkistis
Papamattheou, Eleni
Marinopoulos, Spyridon
Ntanasis-Stathopoulos, Ioannis
Dimitrakakis, Constantine
Giannos, Aris
Kaparelou, Maria
Liontos, Michalis
Dimopoulos, Meletios-Athanasios
Zagouri, Flora
Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature
title Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature
title_full Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature
title_fullStr Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature
title_full_unstemmed Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature
title_short Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature
title_sort metaplastic carcinoma of the breast: case series of a single institute and review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204473/
https://www.ncbi.nlm.nih.gov/pubmed/37218987
http://dx.doi.org/10.3390/medsci11020035
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