Cargando…

Cognitive Test Solution in Mice with Different Brain Weights after Atomoxetine

In this paper, the data are presented concerning different reactions to seven daily injections of atomoxetine in two mouse strains differing in relative brain weight. Atomoxetine affected the performance in a puzzle-box cognitive test in a complicated way—the large brain mice were less successful at...

Descripción completa

Detalles Bibliográficos
Autores principales: Perepelkina, Olga V., Poletaeva, Inga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204487/
https://www.ncbi.nlm.nih.gov/pubmed/37218980
http://dx.doi.org/10.3390/neurolint15020041
_version_ 1785045845593292800
author Perepelkina, Olga V.
Poletaeva, Inga I.
author_facet Perepelkina, Olga V.
Poletaeva, Inga I.
author_sort Perepelkina, Olga V.
collection PubMed
description In this paper, the data are presented concerning different reactions to seven daily injections of atomoxetine in two mouse strains differing in relative brain weight. Atomoxetine affected the performance in a puzzle-box cognitive test in a complicated way—the large brain mice were less successful at task solutions (presumably because they were not afraid of the brightly lit test box), while the small brain strain of atomoxetine treated mice solved the task more successfully. The behavior of all atomoxetine treated animals was more active in an aversive situation (an unescapable slippery funnel, (analogous to the Porsolt test) and the time of immobility decreased significantly in all atomoxetine treated mice. The general patterns of behavioral reactions to atomoxetine in the cognitive test and other interstrain differences demonstrated in these experiments made it possible to suggest that differences in ascending noradrenergic projections between the two strains used exist. Further analysis of the noradrenergic system in these strains is needed (and further analysis of the effects of drugs which affect noradrenergic receptors).
format Online
Article
Text
id pubmed-10204487
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102044872023-05-24 Cognitive Test Solution in Mice with Different Brain Weights after Atomoxetine Perepelkina, Olga V. Poletaeva, Inga I. Neurol Int Article In this paper, the data are presented concerning different reactions to seven daily injections of atomoxetine in two mouse strains differing in relative brain weight. Atomoxetine affected the performance in a puzzle-box cognitive test in a complicated way—the large brain mice were less successful at task solutions (presumably because they were not afraid of the brightly lit test box), while the small brain strain of atomoxetine treated mice solved the task more successfully. The behavior of all atomoxetine treated animals was more active in an aversive situation (an unescapable slippery funnel, (analogous to the Porsolt test) and the time of immobility decreased significantly in all atomoxetine treated mice. The general patterns of behavioral reactions to atomoxetine in the cognitive test and other interstrain differences demonstrated in these experiments made it possible to suggest that differences in ascending noradrenergic projections between the two strains used exist. Further analysis of the noradrenergic system in these strains is needed (and further analysis of the effects of drugs which affect noradrenergic receptors). MDPI 2023-05-15 /pmc/articles/PMC10204487/ /pubmed/37218980 http://dx.doi.org/10.3390/neurolint15020041 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Perepelkina, Olga V.
Poletaeva, Inga I.
Cognitive Test Solution in Mice with Different Brain Weights after Atomoxetine
title Cognitive Test Solution in Mice with Different Brain Weights after Atomoxetine
title_full Cognitive Test Solution in Mice with Different Brain Weights after Atomoxetine
title_fullStr Cognitive Test Solution in Mice with Different Brain Weights after Atomoxetine
title_full_unstemmed Cognitive Test Solution in Mice with Different Brain Weights after Atomoxetine
title_short Cognitive Test Solution in Mice with Different Brain Weights after Atomoxetine
title_sort cognitive test solution in mice with different brain weights after atomoxetine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204487/
https://www.ncbi.nlm.nih.gov/pubmed/37218980
http://dx.doi.org/10.3390/neurolint15020041
work_keys_str_mv AT perepelkinaolgav cognitivetestsolutioninmicewithdifferentbrainweightsafteratomoxetine
AT poletaevaingai cognitivetestsolutioninmicewithdifferentbrainweightsafteratomoxetine