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Cochlear Aqueduct Morphology in Superior Canal Dehiscence Syndrome

The cochlear aqueduct (CA) connects the scala tympani to the subarachnoid space and is thought to assist in pressure regulation of perilymph in normal ears, however, its role and variation in inner ear pathology, such as in superior canal dehiscence syndrome (SCDS), is unknown. This retrospective ra...

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Autores principales: Nagururu, Nimesh V., Jung, Diane, Hui, Ferdinand, Pearl, Monica S., Carey, John P., Ward, Bryan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204506/
https://www.ncbi.nlm.nih.gov/pubmed/37218843
http://dx.doi.org/10.3390/audiolres13030032
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author Nagururu, Nimesh V.
Jung, Diane
Hui, Ferdinand
Pearl, Monica S.
Carey, John P.
Ward, Bryan K.
author_facet Nagururu, Nimesh V.
Jung, Diane
Hui, Ferdinand
Pearl, Monica S.
Carey, John P.
Ward, Bryan K.
author_sort Nagururu, Nimesh V.
collection PubMed
description The cochlear aqueduct (CA) connects the scala tympani to the subarachnoid space and is thought to assist in pressure regulation of perilymph in normal ears, however, its role and variation in inner ear pathology, such as in superior canal dehiscence syndrome (SCDS), is unknown. This retrospective radiographic investigation compared CA measurements and classification, as measured on flat-panel computerized tomography, among three groups of ears: controls, n = 64; anatomic superior canal dehiscence without symptoms (SCD), n = 28; and SCDS, n = 64. We found that in a multinomial logistic regression adjusted for age, sex, and BMI, an increase in CA length by 1 mm was associated with a lower odds for being in the SCDS group vs. control (Odds ratio 0.760 p = 0.005). Hierarchical clustering of continuous CA measures revealed a cluster with small CAs and a cluster with large CAs. Another multinomial logistic regression adjusted for the aforementioned clinical covariates showed an odds ratio of 2.97 for SCDS in the small CA cluster as compared to the large (p = 0.004). Further, no significant association was observed between SCDS symptomatology—vestibular and/or auditory symptoms—and CA structure in SCDS ears. The findings of this study lend support to the hypothesis that SCDS has a congenital etiology.
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spelling pubmed-102045062023-05-24 Cochlear Aqueduct Morphology in Superior Canal Dehiscence Syndrome Nagururu, Nimesh V. Jung, Diane Hui, Ferdinand Pearl, Monica S. Carey, John P. Ward, Bryan K. Audiol Res Article The cochlear aqueduct (CA) connects the scala tympani to the subarachnoid space and is thought to assist in pressure regulation of perilymph in normal ears, however, its role and variation in inner ear pathology, such as in superior canal dehiscence syndrome (SCDS), is unknown. This retrospective radiographic investigation compared CA measurements and classification, as measured on flat-panel computerized tomography, among three groups of ears: controls, n = 64; anatomic superior canal dehiscence without symptoms (SCD), n = 28; and SCDS, n = 64. We found that in a multinomial logistic regression adjusted for age, sex, and BMI, an increase in CA length by 1 mm was associated with a lower odds for being in the SCDS group vs. control (Odds ratio 0.760 p = 0.005). Hierarchical clustering of continuous CA measures revealed a cluster with small CAs and a cluster with large CAs. Another multinomial logistic regression adjusted for the aforementioned clinical covariates showed an odds ratio of 2.97 for SCDS in the small CA cluster as compared to the large (p = 0.004). Further, no significant association was observed between SCDS symptomatology—vestibular and/or auditory symptoms—and CA structure in SCDS ears. The findings of this study lend support to the hypothesis that SCDS has a congenital etiology. MDPI 2023-05-15 /pmc/articles/PMC10204506/ /pubmed/37218843 http://dx.doi.org/10.3390/audiolres13030032 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nagururu, Nimesh V.
Jung, Diane
Hui, Ferdinand
Pearl, Monica S.
Carey, John P.
Ward, Bryan K.
Cochlear Aqueduct Morphology in Superior Canal Dehiscence Syndrome
title Cochlear Aqueduct Morphology in Superior Canal Dehiscence Syndrome
title_full Cochlear Aqueduct Morphology in Superior Canal Dehiscence Syndrome
title_fullStr Cochlear Aqueduct Morphology in Superior Canal Dehiscence Syndrome
title_full_unstemmed Cochlear Aqueduct Morphology in Superior Canal Dehiscence Syndrome
title_short Cochlear Aqueduct Morphology in Superior Canal Dehiscence Syndrome
title_sort cochlear aqueduct morphology in superior canal dehiscence syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204506/
https://www.ncbi.nlm.nih.gov/pubmed/37218843
http://dx.doi.org/10.3390/audiolres13030032
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