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Colonic Ganglioneuroma: A Combined Single-Institution Experience and Review of the Literature of Forty-Three Patients

Ganglioneuromas (GNs) are rare, benign tumors composed of ganglion cells, nerve fibers, and glial cells. Three types of colonic GN lesions exist: polypoid GNs, ganglioneuromatous polyposis, and diffuse ganglioneuromatosis. Less than 100 cases of GN are documented in the literature. A 10-year retrosp...

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Autores principales: Bahmad, Hisham F., Trinh, Sally, Qian, Linda, Terp, Kristy, Alloush, Ferial, Elajami, Mohamad K., Kilinc, Ekim, Poppiti, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204557/
https://www.ncbi.nlm.nih.gov/pubmed/37218882
http://dx.doi.org/10.3390/diseases11020069
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author Bahmad, Hisham F.
Trinh, Sally
Qian, Linda
Terp, Kristy
Alloush, Ferial
Elajami, Mohamad K.
Kilinc, Ekim
Poppiti, Robert
author_facet Bahmad, Hisham F.
Trinh, Sally
Qian, Linda
Terp, Kristy
Alloush, Ferial
Elajami, Mohamad K.
Kilinc, Ekim
Poppiti, Robert
author_sort Bahmad, Hisham F.
collection PubMed
description Ganglioneuromas (GNs) are rare, benign tumors composed of ganglion cells, nerve fibers, and glial cells. Three types of colonic GN lesions exist: polypoid GNs, ganglioneuromatous polyposis, and diffuse ganglioneuromatosis. Less than 100 cases of GN are documented in the literature. A 10-year retrospective search of the pathology database at our institution identified eight cases of colonic GNs. All cases were incidental. Seven of the eight cases presented with colonoscopy findings of small sessile polyps (ranging between 0.1 and 0.7 cm) treated with polypectomy, whereas one case showed a 4 cm partially circumferential and partially obstructing mass in the ascending colon, treated with right hemicolectomy. Almost two-thirds of the cases (5/8) demonstrated associated diverticulosis. All cases were positive for S100 protein and Synaptophysin via immunohistochemistry (IHC). No syndromic association was identified in any of the cases. We also conducted a comprehensive review using PubMed to identify cases of colonic GN reported in the literature. In total, 173 studies were retrieved, among which 36 articles met our inclusion criteria (35 patients and 3 cases on animals). We conclude that while most GNs are incidental and solitary small sessile lesions, many can be diffuse and associated with syndromes. In these cases, the tumor can result in bowel obstruction simulating adenocarcinoma.
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spelling pubmed-102045572023-05-24 Colonic Ganglioneuroma: A Combined Single-Institution Experience and Review of the Literature of Forty-Three Patients Bahmad, Hisham F. Trinh, Sally Qian, Linda Terp, Kristy Alloush, Ferial Elajami, Mohamad K. Kilinc, Ekim Poppiti, Robert Diseases Article Ganglioneuromas (GNs) are rare, benign tumors composed of ganglion cells, nerve fibers, and glial cells. Three types of colonic GN lesions exist: polypoid GNs, ganglioneuromatous polyposis, and diffuse ganglioneuromatosis. Less than 100 cases of GN are documented in the literature. A 10-year retrospective search of the pathology database at our institution identified eight cases of colonic GNs. All cases were incidental. Seven of the eight cases presented with colonoscopy findings of small sessile polyps (ranging between 0.1 and 0.7 cm) treated with polypectomy, whereas one case showed a 4 cm partially circumferential and partially obstructing mass in the ascending colon, treated with right hemicolectomy. Almost two-thirds of the cases (5/8) demonstrated associated diverticulosis. All cases were positive for S100 protein and Synaptophysin via immunohistochemistry (IHC). No syndromic association was identified in any of the cases. We also conducted a comprehensive review using PubMed to identify cases of colonic GN reported in the literature. In total, 173 studies were retrieved, among which 36 articles met our inclusion criteria (35 patients and 3 cases on animals). We conclude that while most GNs are incidental and solitary small sessile lesions, many can be diffuse and associated with syndromes. In these cases, the tumor can result in bowel obstruction simulating adenocarcinoma. MDPI 2023-05-06 /pmc/articles/PMC10204557/ /pubmed/37218882 http://dx.doi.org/10.3390/diseases11020069 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bahmad, Hisham F.
Trinh, Sally
Qian, Linda
Terp, Kristy
Alloush, Ferial
Elajami, Mohamad K.
Kilinc, Ekim
Poppiti, Robert
Colonic Ganglioneuroma: A Combined Single-Institution Experience and Review of the Literature of Forty-Three Patients
title Colonic Ganglioneuroma: A Combined Single-Institution Experience and Review of the Literature of Forty-Three Patients
title_full Colonic Ganglioneuroma: A Combined Single-Institution Experience and Review of the Literature of Forty-Three Patients
title_fullStr Colonic Ganglioneuroma: A Combined Single-Institution Experience and Review of the Literature of Forty-Three Patients
title_full_unstemmed Colonic Ganglioneuroma: A Combined Single-Institution Experience and Review of the Literature of Forty-Three Patients
title_short Colonic Ganglioneuroma: A Combined Single-Institution Experience and Review of the Literature of Forty-Three Patients
title_sort colonic ganglioneuroma: a combined single-institution experience and review of the literature of forty-three patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204557/
https://www.ncbi.nlm.nih.gov/pubmed/37218882
http://dx.doi.org/10.3390/diseases11020069
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