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Innate immune regulations and various siRNA modalities
RNAi therapeutics are designed to produce the precise silencing effects against the gene-linked diseases which were known to be untreatable in the past. The highly immunostimulatory nature of siRNA enhances the off-target effects and easily get attacked by nucleases; hence, their modulation is essen...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer US
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204684/ https://www.ncbi.nlm.nih.gov/pubmed/37219704 http://dx.doi.org/10.1007/s13346-023-01361-4 |