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Lipid droplet biogenesis and functions in health and disease
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being recognized for their versatility beyond energy storage. Advances uncovering the intricacies of their biogenesis and the diversity of their physiological and pathological roles have yielded new insights int...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204695/ https://www.ncbi.nlm.nih.gov/pubmed/37221402 http://dx.doi.org/10.1038/s41574-023-00845-0 |
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author | Zadoorian, Armella Du, Ximing Yang, Hongyuan |
author_facet | Zadoorian, Armella Du, Ximing Yang, Hongyuan |
author_sort | Zadoorian, Armella |
collection | PubMed |
description | Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being recognized for their versatility beyond energy storage. Advances uncovering the intricacies of their biogenesis and the diversity of their physiological and pathological roles have yielded new insights into lipid droplet biology. Despite these insights, the mechanisms governing the biogenesis and functions of lipid droplets remain incompletely understood. Moreover, the causal relationship between the biogenesis and function of lipid droplets and human diseases is poorly resolved. Here, we provide an update on the current understanding of the biogenesis and functions of lipid droplets in health and disease, highlighting a key role for lipid droplet biogenesis in alleviating cellular stresses. We also discuss therapeutic strategies of targeting lipid droplet biogenesis, growth or degradation that could be applied in the future to common diseases, such as cancer, hepatic steatosis and viral infection. |
format | Online Article Text |
id | pubmed-10204695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102046952023-05-25 Lipid droplet biogenesis and functions in health and disease Zadoorian, Armella Du, Ximing Yang, Hongyuan Nat Rev Endocrinol Review Article Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being recognized for their versatility beyond energy storage. Advances uncovering the intricacies of their biogenesis and the diversity of their physiological and pathological roles have yielded new insights into lipid droplet biology. Despite these insights, the mechanisms governing the biogenesis and functions of lipid droplets remain incompletely understood. Moreover, the causal relationship between the biogenesis and function of lipid droplets and human diseases is poorly resolved. Here, we provide an update on the current understanding of the biogenesis and functions of lipid droplets in health and disease, highlighting a key role for lipid droplet biogenesis in alleviating cellular stresses. We also discuss therapeutic strategies of targeting lipid droplet biogenesis, growth or degradation that could be applied in the future to common diseases, such as cancer, hepatic steatosis and viral infection. Nature Publishing Group UK 2023-05-23 /pmc/articles/PMC10204695/ /pubmed/37221402 http://dx.doi.org/10.1038/s41574-023-00845-0 Text en © Springer Nature Limited 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Zadoorian, Armella Du, Ximing Yang, Hongyuan Lipid droplet biogenesis and functions in health and disease |
title | Lipid droplet biogenesis and functions in health and disease |
title_full | Lipid droplet biogenesis and functions in health and disease |
title_fullStr | Lipid droplet biogenesis and functions in health and disease |
title_full_unstemmed | Lipid droplet biogenesis and functions in health and disease |
title_short | Lipid droplet biogenesis and functions in health and disease |
title_sort | lipid droplet biogenesis and functions in health and disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204695/ https://www.ncbi.nlm.nih.gov/pubmed/37221402 http://dx.doi.org/10.1038/s41574-023-00845-0 |
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