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Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment

Traditional Chinese medicine, such as Tripterygium wilfordii and Paeonia lactiflora, has potential values in treating systemic sclerosis (SSc) and other autoimmune diseases, while their toxic side effect elimination and precise tropical drug delivery are still challenges. Here, we present multiple t...

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Detalles Bibliográficos
Autores principales: Luan, Xi, Zhang, Xiaoxuan, Nie, Min, Zhao, Yuanjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204745/
https://www.ncbi.nlm.nih.gov/pubmed/37228639
http://dx.doi.org/10.34133/research.0141
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author Luan, Xi
Zhang, Xiaoxuan
Nie, Min
Zhao, Yuanjin
author_facet Luan, Xi
Zhang, Xiaoxuan
Nie, Min
Zhao, Yuanjin
author_sort Luan, Xi
collection PubMed
description Traditional Chinese medicine, such as Tripterygium wilfordii and Paeonia lactiflora, has potential values in treating systemic sclerosis (SSc) and other autoimmune diseases, while their toxic side effect elimination and precise tropical drug delivery are still challenges. Here, we present multiple traditional Chinese medicine integrated photoresponsive black phosphorus (BP) microneedles (MNs) with the desired features for the SSc treatment. By employing a template-assisted layer-by-layer curing method, such MNs with triptolide (TP)/paeoniflorin (Pae) needle tips and BP-hydrogel needle bottoms could be well generated. The combined administration of TP and Pae can not only provide anti-inflammatory, detoxification, and immunomodulatory effects to treat skin lesions in the early stage of SSc but also remarkably reduce the toxicity of single drug delivery. Besides, the additive BPs possess good biocompatibility and near-infrared (NIR) responsiveness, imparting the MN photothermal-controlled drug release capability. Based on these features, we have demonstrated that the traditional Chinese medicine integrated responsive MNs could effectively improve skin fibrosis and telangiectasia, reduce collagen deposition, and reduce epidermal thickness in the SSc mouse models. These results indicated that the proposed Chinese medicine integrated responsive MNs had enormous potential in clinical therapy of SSc and other diseases.
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spelling pubmed-102047452023-05-24 Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment Luan, Xi Zhang, Xiaoxuan Nie, Min Zhao, Yuanjin Research (Wash D C) Research Article Traditional Chinese medicine, such as Tripterygium wilfordii and Paeonia lactiflora, has potential values in treating systemic sclerosis (SSc) and other autoimmune diseases, while their toxic side effect elimination and precise tropical drug delivery are still challenges. Here, we present multiple traditional Chinese medicine integrated photoresponsive black phosphorus (BP) microneedles (MNs) with the desired features for the SSc treatment. By employing a template-assisted layer-by-layer curing method, such MNs with triptolide (TP)/paeoniflorin (Pae) needle tips and BP-hydrogel needle bottoms could be well generated. The combined administration of TP and Pae can not only provide anti-inflammatory, detoxification, and immunomodulatory effects to treat skin lesions in the early stage of SSc but also remarkably reduce the toxicity of single drug delivery. Besides, the additive BPs possess good biocompatibility and near-infrared (NIR) responsiveness, imparting the MN photothermal-controlled drug release capability. Based on these features, we have demonstrated that the traditional Chinese medicine integrated responsive MNs could effectively improve skin fibrosis and telangiectasia, reduce collagen deposition, and reduce epidermal thickness in the SSc mouse models. These results indicated that the proposed Chinese medicine integrated responsive MNs had enormous potential in clinical therapy of SSc and other diseases. AAAS 2023-05-09 /pmc/articles/PMC10204745/ /pubmed/37228639 http://dx.doi.org/10.34133/research.0141 Text en Copyright © 2023 Xi Luan et al. https://creativecommons.org/licenses/by/4.0/Exclusive licensee Science and Technology Review Publishing House. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Luan, Xi
Zhang, Xiaoxuan
Nie, Min
Zhao, Yuanjin
Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment
title Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment
title_full Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment
title_fullStr Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment
title_full_unstemmed Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment
title_short Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment
title_sort traditional chinese medicine integrated responsive microneedles for systemic sclerosis treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204745/
https://www.ncbi.nlm.nih.gov/pubmed/37228639
http://dx.doi.org/10.34133/research.0141
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