Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats

Introduction: An active metabolite of buprenorphine (BUP), called norbuprenorphine (NorBUP), is implicated in neonatal opioid withdrawal syndrome when BUP is taken during pregnancy. Therefore, reducing or eliminating metabolism of BUP to NorBUP is a novel strategy that will likely lower total fetal...

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Detalles Bibliográficos
Autores principales: Janganati, Venumadhav, Salazar, Paloma, Parks, Brian J., Gorman, Gregory S., Prather, Paul L., Peterson, Eric C., Alund, Alexander W., Moran, Jeffery H., Crooks, Peter A., Brents, Lisa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204800/
https://www.ncbi.nlm.nih.gov/pubmed/37229250
http://dx.doi.org/10.3389/fphar.2023.1123261

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