Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD

RATIONALE: Pulmonary surfactant is vital for lung homeostasis as it reduces surface tension to prevent alveolar collapse and provides essential immune-regulatory and antipathogenic functions. Previous studies demonstrated dysregulation of some individual surfactant components in COPD. We investigate...

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Detalles Bibliográficos
Autores principales: Hristova, Ventzislava A., Watson, Alastair, Chaerkady, Raghothama, Glover, Matthew S., Ackland, Jodie, Angerman, Bastian, Belfield, Graham, Belvisi, Maria G., Burke, Hannah, Cellura, Doriana, Clark, Howard W., Etal, Damla, Freeman, Anna, Heinson, Ashley I., Hess, Sonja, Hühn, Michael, Hall, Emily, Mackay, Alex, Madsen, Jens, McCrae, Christopher, Muthas, Daniel, Novick, Steven, Ostridge, Kristoffer, Öberg, Lisa, Platt, Adam, Postle, Anthony D., Spalluto, C. Mirella, Vaarala, Outi, Wang, Junmin, Staples, Karl J., Wilkinson, Tom M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204810/
https://www.ncbi.nlm.nih.gov/pubmed/37228288
http://dx.doi.org/10.1183/23120541.00378-2022

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