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Increased expression of miR146a dysregulates TLR2-induced HBD2 in airway epithelial cells from patients with COPD

BACKGROUND: Airway epithelial cells from patients with COPD show suboptimal innate immune responses to nontypeable Haemophilus influenzae (NTHi) and Toll-like receptor (TLR)2 ligands despite expressing TLR2 similar to normal airway epithelial cells, but the underlying mechanisms are poorly understoo...

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Detalles Bibliográficos
Autores principales:	Reddy-Vari, Hymavathi, Kim, Yerin, Rajput, Charu, Sajjan, Umadevi S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2023
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204848/ https://www.ncbi.nlm.nih.gov/pubmed/37228294 http://dx.doi.org/10.1183/23120541.00694-2022

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