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Association Between Hemoglobin Glycation Index and Metabolic Syndrome in Middle-Aged and Older People

PURPOSE: Hemoglobin glycation index (HGI) is used to describe the difference between estimated and measured glycated hemoglobin A1c (HbA1c). The present study aimed to investigate the association between metabolic syndrome (MetS) and HGI in middle-aged and elderly Chinese. PATIENTS AND METHODS: In t...

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Autores principales: Xie, Si-si, Luo, Xiao-ting, Dong, Ming-hua, Wang, Qi, Li, Jian, Wu, Qing-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204862/
https://www.ncbi.nlm.nih.gov/pubmed/37229354
http://dx.doi.org/10.2147/DMSO.S406660
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author Xie, Si-si
Luo, Xiao-ting
Dong, Ming-hua
Wang, Qi
Li, Jian
Wu, Qing-feng
author_facet Xie, Si-si
Luo, Xiao-ting
Dong, Ming-hua
Wang, Qi
Li, Jian
Wu, Qing-feng
author_sort Xie, Si-si
collection PubMed
description PURPOSE: Hemoglobin glycation index (HGI) is used to describe the difference between estimated and measured glycated hemoglobin A1c (HbA1c). The present study aimed to investigate the association between metabolic syndrome (MetS) and HGI in middle-aged and elderly Chinese. PATIENTS AND METHODS: In this cross-sectional study, a multi-stage random sampling method was used to select objects from the permanent residents aged 35 years and above living in Ganzhou, Jiangxi, China. The demographic information, history of illness, physical examination, and blood biochemistry data were obtained. HGI was calculated from fasting plasma glucose (FPG) and HbA1c (HGI = measured HbA1c value - predicted HbA1c value). All participants were divided into low HGI and high HGI groups using the median HGI as a cut-off value. Univariate analysis was used to detect the influencing factors of HGI, and Logistic regression analysis was adopted to analyze the relationship between significant variables found in univariate analysis, MetS, or MetS’s components and HGI. RESULTS: A total of 1826 participants were enrolled in the study, and the prevalence of MetS was 27.4%. There were 908 in the low HGI group and 918 in the high HGI group, and the prevalence of MetS was 23.7% and 31.0%, respectively. Logistic regression analysis showed that the prevalence of MetS in the high HGI group was higher than that in the low HGI group (OR=1.384, 95% CI:1.110~1.725), further analysis showed that HGI was related with abdominal obesity (OR=1.287, 95% CI:1.061~1.561), hypertension (OR=1.349, 95% CI:1.115~1.632), and hypercholesterolemia (OR=1.376, 95% CI:1.124~1.684) (all P < 0.05). After adjusting for age, sex, and serum uric acid (UA), the relationship still existed. CONCLUSION: This study found that HGI is directly associated with MetS.
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spelling pubmed-102048622023-05-24 Association Between Hemoglobin Glycation Index and Metabolic Syndrome in Middle-Aged and Older People Xie, Si-si Luo, Xiao-ting Dong, Ming-hua Wang, Qi Li, Jian Wu, Qing-feng Diabetes Metab Syndr Obes Original Research PURPOSE: Hemoglobin glycation index (HGI) is used to describe the difference between estimated and measured glycated hemoglobin A1c (HbA1c). The present study aimed to investigate the association between metabolic syndrome (MetS) and HGI in middle-aged and elderly Chinese. PATIENTS AND METHODS: In this cross-sectional study, a multi-stage random sampling method was used to select objects from the permanent residents aged 35 years and above living in Ganzhou, Jiangxi, China. The demographic information, history of illness, physical examination, and blood biochemistry data were obtained. HGI was calculated from fasting plasma glucose (FPG) and HbA1c (HGI = measured HbA1c value - predicted HbA1c value). All participants were divided into low HGI and high HGI groups using the median HGI as a cut-off value. Univariate analysis was used to detect the influencing factors of HGI, and Logistic regression analysis was adopted to analyze the relationship between significant variables found in univariate analysis, MetS, or MetS’s components and HGI. RESULTS: A total of 1826 participants were enrolled in the study, and the prevalence of MetS was 27.4%. There were 908 in the low HGI group and 918 in the high HGI group, and the prevalence of MetS was 23.7% and 31.0%, respectively. Logistic regression analysis showed that the prevalence of MetS in the high HGI group was higher than that in the low HGI group (OR=1.384, 95% CI:1.110~1.725), further analysis showed that HGI was related with abdominal obesity (OR=1.287, 95% CI:1.061~1.561), hypertension (OR=1.349, 95% CI:1.115~1.632), and hypercholesterolemia (OR=1.376, 95% CI:1.124~1.684) (all P < 0.05). After adjusting for age, sex, and serum uric acid (UA), the relationship still existed. CONCLUSION: This study found that HGI is directly associated with MetS. Dove 2023-05-19 /pmc/articles/PMC10204862/ /pubmed/37229354 http://dx.doi.org/10.2147/DMSO.S406660 Text en © 2023 Xie et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Xie, Si-si
Luo, Xiao-ting
Dong, Ming-hua
Wang, Qi
Li, Jian
Wu, Qing-feng
Association Between Hemoglobin Glycation Index and Metabolic Syndrome in Middle-Aged and Older People
title Association Between Hemoglobin Glycation Index and Metabolic Syndrome in Middle-Aged and Older People
title_full Association Between Hemoglobin Glycation Index and Metabolic Syndrome in Middle-Aged and Older People
title_fullStr Association Between Hemoglobin Glycation Index and Metabolic Syndrome in Middle-Aged and Older People
title_full_unstemmed Association Between Hemoglobin Glycation Index and Metabolic Syndrome in Middle-Aged and Older People
title_short Association Between Hemoglobin Glycation Index and Metabolic Syndrome in Middle-Aged and Older People
title_sort association between hemoglobin glycation index and metabolic syndrome in middle-aged and older people
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204862/
https://www.ncbi.nlm.nih.gov/pubmed/37229354
http://dx.doi.org/10.2147/DMSO.S406660
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