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Guiding protein design choices by per-residue energy breakdown analysis with an interactive web application

Recent developments in machine learning have greatly facilitated the design of proteins with improved properties. However, accurately assessing the contributions of an individual or multiple amino acid mutations to overall protein stability to select the most promising mutants remains a challenge. K...

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Detalles Bibliográficos
Autores principales: Engelberger, Felipe, Zakary, Jonathan D., Künze, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204868/
https://www.ncbi.nlm.nih.gov/pubmed/37228581
http://dx.doi.org/10.3389/fmolb.2023.1178035

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