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Analysis of aptamer-target binding and molecular mechanisms by thermofluorimetric analysis and molecular dynamics simulation

Introduction: Aptamers are valuable for bioassays, but aptamer-target binding is susceptible to reaction conditions. In this study, we combined thermofluorimetric analysis (TFA) and molecular dynamics (MD) simulations to optimize aptamer-target binding, explore underlying mechanisms and select prefe...

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Detalles Bibliográficos
Autores principales:	Zhang, Hong-Li, Lv, Cong, Li, Zi-Hua, Jiang, Song, Cai, Dan, Liu, Shao-Song, Wang, Ting, Zhang, Kun-He
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204870/ https://www.ncbi.nlm.nih.gov/pubmed/37228865 http://dx.doi.org/10.3389/fchem.2023.1144347

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