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Peptides and peptidomimetics as a therapeutic candidate for the treatment of COVID-19: A brief review
Novel SARS-CoV-2 (COVID-19) is affecting worldwide as declared pandemic by the WHO. Various repositioning and novel therapeutic agents are being evaluated under different clinical setups; however, there is no promising therapeutic agent reported to date. Small molecules like peptides have their popu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204890/ https://www.ncbi.nlm.nih.gov/pubmed/36960521 http://dx.doi.org/10.4103/ijp.ijp_700_22 |
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author | Kumaravel, J. Singh, Harvinder Kaur, Sukhmeet Prakash, Ajay Medhi, Bikash |
author_facet | Kumaravel, J. Singh, Harvinder Kaur, Sukhmeet Prakash, Ajay Medhi, Bikash |
author_sort | Kumaravel, J. |
collection | PubMed |
description | Novel SARS-CoV-2 (COVID-19) is affecting worldwide as declared pandemic by the WHO. Various repositioning and novel therapeutic agents are being evaluated under different clinical setups; however, there is no promising therapeutic agent reported to date. Small molecules like peptides have their popularity as their specificity, delivery, and synthesizability as promising therapeutic agents. In this study, we have reviewed the published literature describing peptide designing, in silico binding mode, antiviral activity, preventive measures, and in vivo assessments. Here, we reported all the results which are promising against SARS-CoV-2 as therapeutic and preventive (vaccine candidates), and their status in the drug development process. |
format | Online Article Text |
id | pubmed-10204890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-102048902023-05-24 Peptides and peptidomimetics as a therapeutic candidate for the treatment of COVID-19: A brief review Kumaravel, J. Singh, Harvinder Kaur, Sukhmeet Prakash, Ajay Medhi, Bikash Indian J Pharmacol Short Communication Novel SARS-CoV-2 (COVID-19) is affecting worldwide as declared pandemic by the WHO. Various repositioning and novel therapeutic agents are being evaluated under different clinical setups; however, there is no promising therapeutic agent reported to date. Small molecules like peptides have their popularity as their specificity, delivery, and synthesizability as promising therapeutic agents. In this study, we have reviewed the published literature describing peptide designing, in silico binding mode, antiviral activity, preventive measures, and in vivo assessments. Here, we reported all the results which are promising against SARS-CoV-2 as therapeutic and preventive (vaccine candidates), and their status in the drug development process. Wolters Kluwer - Medknow 2023 2023-03-20 /pmc/articles/PMC10204890/ /pubmed/36960521 http://dx.doi.org/10.4103/ijp.ijp_700_22 Text en Copyright: © 2023 Indian Journal of Pharmacology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Short Communication Kumaravel, J. Singh, Harvinder Kaur, Sukhmeet Prakash, Ajay Medhi, Bikash Peptides and peptidomimetics as a therapeutic candidate for the treatment of COVID-19: A brief review |
title | Peptides and peptidomimetics as a therapeutic candidate for the treatment of COVID-19: A brief review |
title_full | Peptides and peptidomimetics as a therapeutic candidate for the treatment of COVID-19: A brief review |
title_fullStr | Peptides and peptidomimetics as a therapeutic candidate for the treatment of COVID-19: A brief review |
title_full_unstemmed | Peptides and peptidomimetics as a therapeutic candidate for the treatment of COVID-19: A brief review |
title_short | Peptides and peptidomimetics as a therapeutic candidate for the treatment of COVID-19: A brief review |
title_sort | peptides and peptidomimetics as a therapeutic candidate for the treatment of covid-19: a brief review |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204890/ https://www.ncbi.nlm.nih.gov/pubmed/36960521 http://dx.doi.org/10.4103/ijp.ijp_700_22 |
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