Cargando…

Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

Phage therapy is a medical form of biological control of bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage therapy nonetheless is currently experiencing a resurgence in interest, with growing...

Descripción completa

Detalles Bibliográficos
Autores principales: Petrovic Fabijan, Aleksandra, Iredell, Jonathan, Danis-Wlodarczyk, Katarzyna, Kebriaei, Razieh, Abedon, Stephen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204993/
https://www.ncbi.nlm.nih.gov/pubmed/37220114
http://dx.doi.org/10.1371/journal.pbio.3002119
_version_ 1785045946932920320
author Petrovic Fabijan, Aleksandra
Iredell, Jonathan
Danis-Wlodarczyk, Katarzyna
Kebriaei, Razieh
Abedon, Stephen T.
author_facet Petrovic Fabijan, Aleksandra
Iredell, Jonathan
Danis-Wlodarczyk, Katarzyna
Kebriaei, Razieh
Abedon, Stephen T.
author_sort Petrovic Fabijan, Aleksandra
collection PubMed
description Phage therapy is a medical form of biological control of bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage therapy nonetheless is currently experiencing a resurgence in interest, with growing numbers of clinical case studies being published. This renewed enthusiasm is due in large part to phage therapy holding promise for providing safe and effective cures for bacterial infections that traditional antibiotics acting alone have been unable to clear. This Essay introduces basic phage biology, provides an outline of the long history of phage therapy, highlights some advantages of using phages as antibacterial agents, and provides an overview of recent phage therapy clinical successes. Although phage therapy has clear clinical potential, it faces biological, regulatory, and economic challenges to its further implementation and more mainstream acceptance.
format Online
Article
Text
id pubmed-10204993
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-102049932023-05-24 Translating phage therapy into the clinic: Recent accomplishments but continuing challenges Petrovic Fabijan, Aleksandra Iredell, Jonathan Danis-Wlodarczyk, Katarzyna Kebriaei, Razieh Abedon, Stephen T. PLoS Biol Essay Phage therapy is a medical form of biological control of bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage therapy nonetheless is currently experiencing a resurgence in interest, with growing numbers of clinical case studies being published. This renewed enthusiasm is due in large part to phage therapy holding promise for providing safe and effective cures for bacterial infections that traditional antibiotics acting alone have been unable to clear. This Essay introduces basic phage biology, provides an outline of the long history of phage therapy, highlights some advantages of using phages as antibacterial agents, and provides an overview of recent phage therapy clinical successes. Although phage therapy has clear clinical potential, it faces biological, regulatory, and economic challenges to its further implementation and more mainstream acceptance. Public Library of Science 2023-05-23 /pmc/articles/PMC10204993/ /pubmed/37220114 http://dx.doi.org/10.1371/journal.pbio.3002119 Text en © 2023 Petrovic Fabijan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Essay
Petrovic Fabijan, Aleksandra
Iredell, Jonathan
Danis-Wlodarczyk, Katarzyna
Kebriaei, Razieh
Abedon, Stephen T.
Translating phage therapy into the clinic: Recent accomplishments but continuing challenges
title Translating phage therapy into the clinic: Recent accomplishments but continuing challenges
title_full Translating phage therapy into the clinic: Recent accomplishments but continuing challenges
title_fullStr Translating phage therapy into the clinic: Recent accomplishments but continuing challenges
title_full_unstemmed Translating phage therapy into the clinic: Recent accomplishments but continuing challenges
title_short Translating phage therapy into the clinic: Recent accomplishments but continuing challenges
title_sort translating phage therapy into the clinic: recent accomplishments but continuing challenges
topic Essay
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204993/
https://www.ncbi.nlm.nih.gov/pubmed/37220114
http://dx.doi.org/10.1371/journal.pbio.3002119
work_keys_str_mv AT petrovicfabijanaleksandra translatingphagetherapyintotheclinicrecentaccomplishmentsbutcontinuingchallenges
AT iredelljonathan translatingphagetherapyintotheclinicrecentaccomplishmentsbutcontinuingchallenges
AT daniswlodarczykkatarzyna translatingphagetherapyintotheclinicrecentaccomplishmentsbutcontinuingchallenges
AT kebriaeirazieh translatingphagetherapyintotheclinicrecentaccomplishmentsbutcontinuingchallenges
AT abedonstephent translatingphagetherapyintotheclinicrecentaccomplishmentsbutcontinuingchallenges