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Translating phage therapy into the clinic: Recent accomplishments but continuing challenges
Phage therapy is a medical form of biological control of bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage therapy nonetheless is currently experiencing a resurgence in interest, with growing...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204993/ https://www.ncbi.nlm.nih.gov/pubmed/37220114 http://dx.doi.org/10.1371/journal.pbio.3002119 |
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author | Petrovic Fabijan, Aleksandra Iredell, Jonathan Danis-Wlodarczyk, Katarzyna Kebriaei, Razieh Abedon, Stephen T. |
author_facet | Petrovic Fabijan, Aleksandra Iredell, Jonathan Danis-Wlodarczyk, Katarzyna Kebriaei, Razieh Abedon, Stephen T. |
author_sort | Petrovic Fabijan, Aleksandra |
collection | PubMed |
description | Phage therapy is a medical form of biological control of bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage therapy nonetheless is currently experiencing a resurgence in interest, with growing numbers of clinical case studies being published. This renewed enthusiasm is due in large part to phage therapy holding promise for providing safe and effective cures for bacterial infections that traditional antibiotics acting alone have been unable to clear. This Essay introduces basic phage biology, provides an outline of the long history of phage therapy, highlights some advantages of using phages as antibacterial agents, and provides an overview of recent phage therapy clinical successes. Although phage therapy has clear clinical potential, it faces biological, regulatory, and economic challenges to its further implementation and more mainstream acceptance. |
format | Online Article Text |
id | pubmed-10204993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-102049932023-05-24 Translating phage therapy into the clinic: Recent accomplishments but continuing challenges Petrovic Fabijan, Aleksandra Iredell, Jonathan Danis-Wlodarczyk, Katarzyna Kebriaei, Razieh Abedon, Stephen T. PLoS Biol Essay Phage therapy is a medical form of biological control of bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage therapy nonetheless is currently experiencing a resurgence in interest, with growing numbers of clinical case studies being published. This renewed enthusiasm is due in large part to phage therapy holding promise for providing safe and effective cures for bacterial infections that traditional antibiotics acting alone have been unable to clear. This Essay introduces basic phage biology, provides an outline of the long history of phage therapy, highlights some advantages of using phages as antibacterial agents, and provides an overview of recent phage therapy clinical successes. Although phage therapy has clear clinical potential, it faces biological, regulatory, and economic challenges to its further implementation and more mainstream acceptance. Public Library of Science 2023-05-23 /pmc/articles/PMC10204993/ /pubmed/37220114 http://dx.doi.org/10.1371/journal.pbio.3002119 Text en © 2023 Petrovic Fabijan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Essay Petrovic Fabijan, Aleksandra Iredell, Jonathan Danis-Wlodarczyk, Katarzyna Kebriaei, Razieh Abedon, Stephen T. Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
title | Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
title_full | Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
title_fullStr | Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
title_full_unstemmed | Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
title_short | Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
title_sort | translating phage therapy into the clinic: recent accomplishments but continuing challenges |
topic | Essay |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204993/ https://www.ncbi.nlm.nih.gov/pubmed/37220114 http://dx.doi.org/10.1371/journal.pbio.3002119 |
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