Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 M(pro))

The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a great threat to public health while various vaccines are available worldwide. Main protease (M(pro)) has been validated as an effective anti-COVID-19 drug target. Using medicinal chemistry and rational drug design strategies, we identifi...

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Detalles Bibliográficos
Autores principales: Zhang, Kuojun, Wang, Tianyu, Li, Maotian, Liu, Mu, Tang, He, Wang, Lin, Ye, Ke, Yang, Jiamei, Jiang, Sheng, Xiao, Yibei, Xie, Youhua, Lu, Meiling, Zhang, Xiangyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205138/
https://www.ncbi.nlm.nih.gov/pubmed/37257212
http://dx.doi.org/10.1016/j.ejmech.2023.115487

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