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Transit analysis of thyroid antibodies in graves’ disease following painless thyroiditis: a case report

Graves’ disease and painless thyroiditis induce hyperthyroidism and are manifestations of an immunological disorder; however, their clinical entities differ. This case report illustrates a possible interrelation between the pathogenesis of these two disorders. A 34-year-old woman presented with palp...

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Autores principales: Suto, Daisuke, Ebihara, Ken, Ishikawa, San-e
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205256/
https://www.ncbi.nlm.nih.gov/pubmed/37229036
http://dx.doi.org/10.1097/MS9.0000000000000543
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author Suto, Daisuke
Ebihara, Ken
Ishikawa, San-e
author_facet Suto, Daisuke
Ebihara, Ken
Ishikawa, San-e
author_sort Suto, Daisuke
collection PubMed
description Graves’ disease and painless thyroiditis induce hyperthyroidism and are manifestations of an immunological disorder; however, their clinical entities differ. This case report illustrates a possible interrelation between the pathogenesis of these two disorders. A 34-year-old woman presented with palpitations, fatigue, and shortness of breath and was initially diagnosed with painless thyroiditis, which spontaneously normalized within 2 months. Within the euthyroid state, there were atypical alterations in thyroid autoantibodies, namely, activation of the thyroid stimulating hormone receptor antibody and inactivation of thyroid peroxidase and thyroglobulin antibodies. Ten months later, her hyperthyroidism recurred, with this second incidence deemed to be related to Graves’ disease. Our patient had two types of painless thyroiditis with no successive hyperthyroidism, followed by Graves’ disease, with her clinical manifestation transitioning from painless thyroiditis to Graves’ disease over a 20-month period. Future studies are needed to elucidate the mechanisms and relationship between painless thyroiditis and Graves’ disease.
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spelling pubmed-102052562023-05-24 Transit analysis of thyroid antibodies in graves’ disease following painless thyroiditis: a case report Suto, Daisuke Ebihara, Ken Ishikawa, San-e Ann Med Surg (Lond) Case Reports Graves’ disease and painless thyroiditis induce hyperthyroidism and are manifestations of an immunological disorder; however, their clinical entities differ. This case report illustrates a possible interrelation between the pathogenesis of these two disorders. A 34-year-old woman presented with palpitations, fatigue, and shortness of breath and was initially diagnosed with painless thyroiditis, which spontaneously normalized within 2 months. Within the euthyroid state, there were atypical alterations in thyroid autoantibodies, namely, activation of the thyroid stimulating hormone receptor antibody and inactivation of thyroid peroxidase and thyroglobulin antibodies. Ten months later, her hyperthyroidism recurred, with this second incidence deemed to be related to Graves’ disease. Our patient had two types of painless thyroiditis with no successive hyperthyroidism, followed by Graves’ disease, with her clinical manifestation transitioning from painless thyroiditis to Graves’ disease over a 20-month period. Future studies are needed to elucidate the mechanisms and relationship between painless thyroiditis and Graves’ disease. Lippincott Williams & Wilkins 2023-04-11 /pmc/articles/PMC10205256/ /pubmed/37229036 http://dx.doi.org/10.1097/MS9.0000000000000543 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Case Reports
Suto, Daisuke
Ebihara, Ken
Ishikawa, San-e
Transit analysis of thyroid antibodies in graves’ disease following painless thyroiditis: a case report
title Transit analysis of thyroid antibodies in graves’ disease following painless thyroiditis: a case report
title_full Transit analysis of thyroid antibodies in graves’ disease following painless thyroiditis: a case report
title_fullStr Transit analysis of thyroid antibodies in graves’ disease following painless thyroiditis: a case report
title_full_unstemmed Transit analysis of thyroid antibodies in graves’ disease following painless thyroiditis: a case report
title_short Transit analysis of thyroid antibodies in graves’ disease following painless thyroiditis: a case report
title_sort transit analysis of thyroid antibodies in graves’ disease following painless thyroiditis: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205256/
https://www.ncbi.nlm.nih.gov/pubmed/37229036
http://dx.doi.org/10.1097/MS9.0000000000000543
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