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Sensitization to nsLTP: A Retrospective Study in An Italian Pediatric Population over the Last Decade
BACKGROUND: Food allergy is common in the Mediterranean, especially concerning lipid transfer proteins (LTPs) allergy. LTPs are widespread plant food allergens in fruits, vegetables, nuts, pollen, and latex. Also, LTPs are prevalent food allergens in the Mediterranean area. They can sensitize via th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205406/ https://www.ncbi.nlm.nih.gov/pubmed/37228443 http://dx.doi.org/10.1155/2023/4053799 |
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author | Indolfi, Cristiana Dinardo, Giulio Klain, Angela Contieri, Marcella Umano, Giuseppina Rosaria Decimo, Fabio Abbadessa, Salvatore Vitulano, Carolina Ciprandi, Giorgio Miraglia del Giudice, Michele |
author_facet | Indolfi, Cristiana Dinardo, Giulio Klain, Angela Contieri, Marcella Umano, Giuseppina Rosaria Decimo, Fabio Abbadessa, Salvatore Vitulano, Carolina Ciprandi, Giorgio Miraglia del Giudice, Michele |
author_sort | Indolfi, Cristiana |
collection | PubMed |
description | BACKGROUND: Food allergy is common in the Mediterranean, especially concerning lipid transfer proteins (LTPs) allergy. LTPs are widespread plant food allergens in fruits, vegetables, nuts, pollen, and latex. Also, LTPs are prevalent food allergens in the Mediterranean area. They can sensitize via the gastrointestinal tract and cause a wide range of conditions: from mild reactions, such as oral allergy syndrome, to severe reactions, such as anaphylaxis. LTP allergy in the adult population is well described in the literature, concerning both the prevalence and clinical characteristics. However, there is poor knowledge about its prevalence and clinical manifestation in children living in the Mediterranean. MATERIALS AND METHODS: This study, including 800 children aged from 1 to 18 years, investigated the prevalence of 8 different molecules of nonspecific LTP over time in an Italian pediatric population visited over the last 11 years. RESULTS: About 52% of the test population was sensitized to at least one LTP molecule. For all the LTPs analyzed, sensitization increased over time. In particular, using the years 2010 through 2020 as a comparison, the major increases were observed for the LTPs of the English walnut Jug r 3, the peanut Ara h 9, and the plane tree Pla a 3 (about 50%); the increase of the LTP of the Hazelnut Cor a 8 was about 36%, and that of the LTP of the artemisia Art v 3 was approximately 30%. CONCLUSIONS: The latest evidence in the literature indicates an increase in food allergy prevalence in the general population, including children. Therefore, the present survey represents an interesting perspective about the pediatric population of the Mediterranean area, exploring the trend of LTP allergy. |
format | Online Article Text |
id | pubmed-10205406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-102054062023-05-24 Sensitization to nsLTP: A Retrospective Study in An Italian Pediatric Population over the Last Decade Indolfi, Cristiana Dinardo, Giulio Klain, Angela Contieri, Marcella Umano, Giuseppina Rosaria Decimo, Fabio Abbadessa, Salvatore Vitulano, Carolina Ciprandi, Giorgio Miraglia del Giudice, Michele J Immunol Res Research Article BACKGROUND: Food allergy is common in the Mediterranean, especially concerning lipid transfer proteins (LTPs) allergy. LTPs are widespread plant food allergens in fruits, vegetables, nuts, pollen, and latex. Also, LTPs are prevalent food allergens in the Mediterranean area. They can sensitize via the gastrointestinal tract and cause a wide range of conditions: from mild reactions, such as oral allergy syndrome, to severe reactions, such as anaphylaxis. LTP allergy in the adult population is well described in the literature, concerning both the prevalence and clinical characteristics. However, there is poor knowledge about its prevalence and clinical manifestation in children living in the Mediterranean. MATERIALS AND METHODS: This study, including 800 children aged from 1 to 18 years, investigated the prevalence of 8 different molecules of nonspecific LTP over time in an Italian pediatric population visited over the last 11 years. RESULTS: About 52% of the test population was sensitized to at least one LTP molecule. For all the LTPs analyzed, sensitization increased over time. In particular, using the years 2010 through 2020 as a comparison, the major increases were observed for the LTPs of the English walnut Jug r 3, the peanut Ara h 9, and the plane tree Pla a 3 (about 50%); the increase of the LTP of the Hazelnut Cor a 8 was about 36%, and that of the LTP of the artemisia Art v 3 was approximately 30%. CONCLUSIONS: The latest evidence in the literature indicates an increase in food allergy prevalence in the general population, including children. Therefore, the present survey represents an interesting perspective about the pediatric population of the Mediterranean area, exploring the trend of LTP allergy. Hindawi 2023-05-16 /pmc/articles/PMC10205406/ /pubmed/37228443 http://dx.doi.org/10.1155/2023/4053799 Text en Copyright © 2023 Cristiana Indolfi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Indolfi, Cristiana Dinardo, Giulio Klain, Angela Contieri, Marcella Umano, Giuseppina Rosaria Decimo, Fabio Abbadessa, Salvatore Vitulano, Carolina Ciprandi, Giorgio Miraglia del Giudice, Michele Sensitization to nsLTP: A Retrospective Study in An Italian Pediatric Population over the Last Decade |
title | Sensitization to nsLTP: A Retrospective Study in An Italian Pediatric Population over the Last Decade |
title_full | Sensitization to nsLTP: A Retrospective Study in An Italian Pediatric Population over the Last Decade |
title_fullStr | Sensitization to nsLTP: A Retrospective Study in An Italian Pediatric Population over the Last Decade |
title_full_unstemmed | Sensitization to nsLTP: A Retrospective Study in An Italian Pediatric Population over the Last Decade |
title_short | Sensitization to nsLTP: A Retrospective Study in An Italian Pediatric Population over the Last Decade |
title_sort | sensitization to nsltp: a retrospective study in an italian pediatric population over the last decade |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205406/ https://www.ncbi.nlm.nih.gov/pubmed/37228443 http://dx.doi.org/10.1155/2023/4053799 |
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