ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database

Chagas disease is a parasitical disease caused by Trypanosoma cruzi which affects ∼7 million people worldwide. Per year, ∼10 000 people die from this pathology. Indeed, ∼30% of humans develop severe chronic forms, including cardiac, digestive or neurological disorders, for which there is still no tr...

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Autores principales: Brochet, Pauline, Mouren, Jean-Christophe, Hannouche, Laurent, Lopez, Fabrice, Ballester, Benoit, Cunha-Neto, Edecio, Spinelli, Lionel, Chevillard, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Database Tool
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205463/
https://www.ncbi.nlm.nih.gov/pubmed/37221041
http://dx.doi.org/10.1093/database/baad037
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author Brochet, Pauline
Mouren, Jean-Christophe
Hannouche, Laurent
Lopez, Fabrice
Ballester, Benoit
Cunha-Neto, Edecio
Spinelli, Lionel
Chevillard, Christophe
author_facet Brochet, Pauline
Mouren, Jean-Christophe
Hannouche, Laurent
Lopez, Fabrice
Ballester, Benoit
Cunha-Neto, Edecio
Spinelli, Lionel
Chevillard, Christophe
author_sort Brochet, Pauline
collection PubMed
description Chagas disease is a parasitical disease caused by Trypanosoma cruzi which affects ∼7 million people worldwide. Per year, ∼10 000 people die from this pathology. Indeed, ∼30% of humans develop severe chronic forms, including cardiac, digestive or neurological disorders, for which there is still no treatment. In order to facilitate research on Chagas disease, a manual curation of all papers corresponding to ‘Chagas disease’ referenced on PubMed has been performed. All deregulated molecules in hosts (all mammals, humans, mice or others) following T. cruzi infection were retrieved and included in a database, named ChagasDB. A website has been developed to make this database accessible to all. In this article, we detail the construction of this database, its contents and how to use it. Database URL https://chagasdb.tagc.univ-amu.fr
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spelling pubmed-102054632023-05-24 ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database Brochet, Pauline Mouren, Jean-Christophe Hannouche, Laurent Lopez, Fabrice Ballester, Benoit Cunha-Neto, Edecio Spinelli, Lionel Chevillard, Christophe Database (Oxford) Database Tool Chagas disease is a parasitical disease caused by Trypanosoma cruzi which affects ∼7 million people worldwide. Per year, ∼10 000 people die from this pathology. Indeed, ∼30% of humans develop severe chronic forms, including cardiac, digestive or neurological disorders, for which there is still no treatment. In order to facilitate research on Chagas disease, a manual curation of all papers corresponding to ‘Chagas disease’ referenced on PubMed has been performed. All deregulated molecules in hosts (all mammals, humans, mice or others) following T. cruzi infection were retrieved and included in a database, named ChagasDB. A website has been developed to make this database accessible to all. In this article, we detail the construction of this database, its contents and how to use it. Database URL https://chagasdb.tagc.univ-amu.fr Oxford University Press 2023-05-26 /pmc/articles/PMC10205463/ /pubmed/37221041 http://dx.doi.org/10.1093/database/baad037 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database Tool
Brochet, Pauline
Mouren, Jean-Christophe
Hannouche, Laurent
Lopez, Fabrice
Ballester, Benoit
Cunha-Neto, Edecio
Spinelli, Lionel
Chevillard, Christophe
ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database
title ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database
title_full ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database
title_fullStr ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database
title_full_unstemmed ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database
title_short ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database
title_sort chagasdb: 80 years of publicly available data on the molecular host response to trypanosoma cruzi infection in a single database
topic Database Tool
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205463/
https://www.ncbi.nlm.nih.gov/pubmed/37221041
http://dx.doi.org/10.1093/database/baad037
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