Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS

Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular switches in regulating key cellular functions. Their dysregulation is a therapeutic target for tumors, neurodegeneration, cardiomyopathies, and infection. However, small GTPases have been historically recognized as “undrug...

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Detalles Bibliográficos
Autores principales: Yin, Guowei, Huang, Jing, Petela, Johnny, Jiang, Hongmei, Zhang, Yuetong, Gong, Siqi, Wu, Jiaxin, Liu, Bei, Shi, Jianyou, Gao, Yijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205766/
https://www.ncbi.nlm.nih.gov/pubmed/37221195
http://dx.doi.org/10.1038/s41392-023-01441-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205766/
https://www.ncbi.nlm.nih.gov/pubmed/37221195
http://dx.doi.org/10.1038/s41392-023-01441-4

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