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Circulating tumour cells in gastrointestinal cancers: food for thought?

Gastrointestinal (GI) cancers account for 35% of cancer-related deaths, predominantly due to their ability to spread and generate drug-tolerant metastases. Arising from different locations in the GI system, the majority of metastatic GI malignancies colonise the liver and the lungs. In this context,...

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Autores principales: Asawa, Simran, Nüesch, Manuel, Gvozdenovic, Ana, Aceto, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205795/
https://www.ncbi.nlm.nih.gov/pubmed/36932192
http://dx.doi.org/10.1038/s41416-023-02228-8
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author Asawa, Simran
Nüesch, Manuel
Gvozdenovic, Ana
Aceto, Nicola
author_facet Asawa, Simran
Nüesch, Manuel
Gvozdenovic, Ana
Aceto, Nicola
author_sort Asawa, Simran
collection PubMed
description Gastrointestinal (GI) cancers account for 35% of cancer-related deaths, predominantly due to their ability to spread and generate drug-tolerant metastases. Arising from different locations in the GI system, the majority of metastatic GI malignancies colonise the liver and the lungs. In this context, circulating tumour cells (CTCs) are playing a critical role in the formation of new metastases, and their presence in the blood of patients has been correlated with a poor outcome. In addition to their prognostic utility, prospective targeting of CTCs may represent a novel, yet ambitious strategy in the fight against metastasis. A better understanding of CTC biology, mechanistic underpinnings and weaknesses may facilitate the development of previously underappreciated anti-metastasis approaches. Here, along with related clinical studies, we outline a selection of the literature describing biological features of CTCs with an impact on their metastasis forming ability in different GI cancers.
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spelling pubmed-102057952023-05-25 Circulating tumour cells in gastrointestinal cancers: food for thought? Asawa, Simran Nüesch, Manuel Gvozdenovic, Ana Aceto, Nicola Br J Cancer Review Article Gastrointestinal (GI) cancers account for 35% of cancer-related deaths, predominantly due to their ability to spread and generate drug-tolerant metastases. Arising from different locations in the GI system, the majority of metastatic GI malignancies colonise the liver and the lungs. In this context, circulating tumour cells (CTCs) are playing a critical role in the formation of new metastases, and their presence in the blood of patients has been correlated with a poor outcome. In addition to their prognostic utility, prospective targeting of CTCs may represent a novel, yet ambitious strategy in the fight against metastasis. A better understanding of CTC biology, mechanistic underpinnings and weaknesses may facilitate the development of previously underappreciated anti-metastasis approaches. Here, along with related clinical studies, we outline a selection of the literature describing biological features of CTCs with an impact on their metastasis forming ability in different GI cancers. Nature Publishing Group UK 2023-03-17 2023-06-15 /pmc/articles/PMC10205795/ /pubmed/36932192 http://dx.doi.org/10.1038/s41416-023-02228-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Asawa, Simran
Nüesch, Manuel
Gvozdenovic, Ana
Aceto, Nicola
Circulating tumour cells in gastrointestinal cancers: food for thought?
title Circulating tumour cells in gastrointestinal cancers: food for thought?
title_full Circulating tumour cells in gastrointestinal cancers: food for thought?
title_fullStr Circulating tumour cells in gastrointestinal cancers: food for thought?
title_full_unstemmed Circulating tumour cells in gastrointestinal cancers: food for thought?
title_short Circulating tumour cells in gastrointestinal cancers: food for thought?
title_sort circulating tumour cells in gastrointestinal cancers: food for thought?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205795/
https://www.ncbi.nlm.nih.gov/pubmed/36932192
http://dx.doi.org/10.1038/s41416-023-02228-8
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