Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study

Recurrent and disseminated pityriasis versicolor (RDPV) is a common clinical entity, characterized by its recurrent and disfiguring nature. Studies demonstrated host genetic variations in the immune response, especially the role of IL-17 in antifungal immunity. This study aimed to detect whether IL-...

Descripción completa

Detalles Bibliográficos
Autores principales: El-Tahlawi, S. R., Ramadan, A. H., Shaker, O. G., Hilal, R. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205842/
https://www.ncbi.nlm.nih.gov/pubmed/36449073
http://dx.doi.org/10.1007/s00403-022-02462-9
_version_ 1785046111058132992
author El-Tahlawi, S. R.
Ramadan, A. H.
Shaker, O. G.
Hilal, R. F.
author_facet El-Tahlawi, S. R.
Ramadan, A. H.
Shaker, O. G.
Hilal, R. F.
author_sort El-Tahlawi, S. R.
collection PubMed
description Recurrent and disseminated pityriasis versicolor (RDPV) is a common clinical entity, characterized by its recurrent and disfiguring nature. Studies demonstrated host genetic variations in the immune response, especially the role of IL-17 in antifungal immunity. This study aimed to detect whether IL-17A and F gene polymorphisms are found in cases of RDPV. It included 100 cases of RDPV and 100 age and sex matched controls, from which EDTA blood samples were taken for single-nucleotide polymorphism analysis. IL-17A (rs2275913) and F (rs763780) were associated with a significantly increased incidence of developing RDPV. IL-17A and F gene polymorphism could be implicated as a risk factor for the development of RDPV.
format Online
Article
Text
id pubmed-10205842
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-102058422023-05-25 Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study El-Tahlawi, S. R. Ramadan, A. H. Shaker, O. G. Hilal, R. F. Arch Dermatol Res Study Protocol Recurrent and disseminated pityriasis versicolor (RDPV) is a common clinical entity, characterized by its recurrent and disfiguring nature. Studies demonstrated host genetic variations in the immune response, especially the role of IL-17 in antifungal immunity. This study aimed to detect whether IL-17A and F gene polymorphisms are found in cases of RDPV. It included 100 cases of RDPV and 100 age and sex matched controls, from which EDTA blood samples were taken for single-nucleotide polymorphism analysis. IL-17A (rs2275913) and F (rs763780) were associated with a significantly increased incidence of developing RDPV. IL-17A and F gene polymorphism could be implicated as a risk factor for the development of RDPV. Springer Berlin Heidelberg 2022-11-30 2023 /pmc/articles/PMC10205842/ /pubmed/36449073 http://dx.doi.org/10.1007/s00403-022-02462-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Study Protocol
El-Tahlawi, S. R.
Ramadan, A. H.
Shaker, O. G.
Hilal, R. F.
Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study
title Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study
title_full Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study
title_fullStr Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study
title_full_unstemmed Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study
title_short Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study
title_sort detection of il-17a and il-17f gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205842/
https://www.ncbi.nlm.nih.gov/pubmed/36449073
http://dx.doi.org/10.1007/s00403-022-02462-9
work_keys_str_mv AT eltahlawisr detectionofil17aandil17fgenepolymorphisminrecurrentanddisseminatedpityriasisversicoloracasecontrolstudy
AT ramadanah detectionofil17aandil17fgenepolymorphisminrecurrentanddisseminatedpityriasisversicoloracasecontrolstudy
AT shakerog detectionofil17aandil17fgenepolymorphisminrecurrentanddisseminatedpityriasisversicoloracasecontrolstudy
AT hilalrf detectionofil17aandil17fgenepolymorphisminrecurrentanddisseminatedpityriasisversicoloracasecontrolstudy

Ejemplares similares