AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins

We previously reported that kenpaullone, which inhibits GSK-3a/b and CDKs inhibited CCCP mediated mitochondrial depolarisation and augments the mitochondrial network. To investigate the actions of this class of drug further, we compared the ability of kenpaullone, alsterpaullone, 1-azakenapaullone,...

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Detalles Bibliográficos
Autores principales: Shi, Gongyu, Scott, Helen, Azhar, Nur Izzah Farhana Mohamad, Gialeli, Andriana, Clennell, Benjamin, Lee, Keng Siang, Hurcombe, Jenny, Whitcomb, Daniel, Coward, Richard, Wong, Liang-Fong, Cordero-Llana, Oscar, Uney, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205901/
https://www.ncbi.nlm.nih.gov/pubmed/37221196
http://dx.doi.org/10.1038/s41598-023-35480-2

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