Cargando…

Diagnostic rate of germline pathogenic variants in pancreatic ductal adenocarcinoma patients using whole genome sequencing

Identification of germline pathogenic variants in cancer patients is critical for treatment planning, genetic counseling, and health policymaking. However, previous estimates of the prevalence of germline etiology of pancreatic ductal adenocarcinoma (PDAC) were biased because they were based only on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chung, An-Ko, Lin, Ro-Ting, Yeh, Chun-Chieh, Yang, Chi-Ying, Wu, Chang-Jiun, Chen, Pei-Lung, Lin, Jaw-Town
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205989/ https://www.ncbi.nlm.nih.gov/pubmed/37234870 http://dx.doi.org/10.3389/fgene.2023.1172365

Ejemplares similares

Prevalence and Risk Factors of Germline Pathogenic Variants in Pancreatic Ductal Adenocarcinoma
por: Ryu, Kum Hei, et al.
Publicado: (2023)

Endoscopic ultrasound-guided fine-needle biopsy as a tool for studying the intra-tumoral microbiome in pancreatic ductal adenocarcinoma: a pilot study
por: Chu, Chia-Sheng, et al.
Publicado: (2022)

Risk factors related to age at diagnosis of pancreatic cancer: a retrospective cohort pilot study
por: Lin, Ro-Ting, et al.
Publicado: (2022)

Integrated analysis of senescence-associated genes in pancreatic ductal adenocarcinoma
por: Zhu, Zhi-gang, et al.
Publicado: (2022)

Clinically impactful metabolic subtypes of pancreatic ductal adenocarcinoma (PDAC)
por: Pervin, Jannat, et al.
Publicado: (2023)

Clinical study of genomic drivers in pancreatic ductal adenocarcinoma
por: Barrett, Michael T, et al.
Publicado: (2017)

Exploring the key genetic association between chronic pancreatitis and pancreatic ductal adenocarcinoma through integrated bioinformatics
por: Guo, Kai, et al.
Publicado: (2023)

Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma
por: Koh, Youngil, et al.
Publicado: (2023)

Identification and Validation of Prognostic Model for Pancreatic Ductal Adenocarcinoma Based on Necroptosis-Related Genes
por: Xie, Haoran, et al.
Publicado: (2022)

Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma
por: Klett, Hagen, et al.
Publicado: (2018)

Survival Analysis of Multi-Omics Data Identifies Potential Prognostic Markers of Pancreatic Ductal Adenocarcinoma
por: Mishra, Nitish Kumar, et al.
Publicado: (2019)

Glycolysis-Related Gene Expression Profiling Screen for Prognostic Risk Signature of Pancreatic Ductal Adenocarcinoma
por: Song, Wenjing, et al.
Publicado: (2021)

Whole-exome identifies germline variants in families with obstructive sleep apnea syndrome
por: de Azevedo, Pedro Guimarães, et al.
Publicado: (2023)

The Key Genes for Perineural Invasion in Pancreatic Ductal Adenocarcinoma Identified With Monte-Carlo Feature Selection Method
por: Zhu, Jin-Hui, et al.
Publicado: (2020)

Expression of HOXC8 is inversely related to the progression and metastasis of pancreatic ductal adenocarcinoma
por: Adwan, H, et al.
Publicado: (2011)

Frequent cleft lip and palate in families with pathogenic germline CDH1 variants
por: Green, Benjamin L., et al.
Publicado: (2022)

Pancreaticoduodenectomy of Pancreatic Ductal Adenocarcinoma in the Elderly
por: Kang, Chang Moo, et al.
Publicado: (2007)

New Pathogenic Germline Variants in Very Early Onset and Familial Colorectal Cancer Patients
por: Djursby, Malene, et al.
Publicado: (2020)

Prognostic N6-methyladenosine (m6A)-related lncRNA patterns to aid therapy in pancreatic ductal adenocarcinoma
por: Wang, Yuxin, et al.
Publicado: (2022)

Pathogenic germline variants in patients with breast cancer: conversations across generations, practices and patients’ attitude
por: Abdel-Razeq, Hikmat, et al.
Publicado: (2023)

Burden of hereditary cancer susceptibility in unselected patients with pancreatic ductal adenocarcinoma referred for germline screening
por: Cremin, Carol, et al.
Publicado: (2020)

A Ductal-Cell-Related Risk Model Integrating Single-Cell and Bulk Sequencing Data Predicts the Prognosis of Patients With Pancreatic Adenocarcinoma
por: Wang, Xitao, et al.
Publicado: (2022)

Case Report: Novel pathogenic variant in NFIX in two sisters with Malan syndrome due to germline mosaicism
por: Langley, Elizabeth, et al.
Publicado: (2022)

Whole-Exome Sequencing Reveals Rare Germline Mutations in Patients With Hemifacial Microsomia
por: Chen, Xiaojun, et al.
Publicado: (2021)

Chemotherapy toxicity and activity in patients with pancreatic ductal adenocarcinoma and germline BRCA1-2 pathogenic variants (gBRCA1-2pv): a multicenter survey
por: Orsi, G., et al.
Publicado: (2021)

Identification of the Germline Mutation Profile in Esophageal Squamous Cell Carcinoma by Whole Exome Sequencing
por: Deng, Jiaying, et al.
Publicado: (2019)

Germline sequence analysis of RABL3 in a large series of pancreatic ductal adenocarcinoma patients reveals no evidence of deleterious variants
por: Roberts, Nicholas J., et al.
Publicado: (2021)

Case Report: Identification of a Novel Pathogenic Germline TP53 Variant in a Family With Li–Fraumeni Syndrome
por: Paduano, Francesco, et al.
Publicado: (2021)

The prevalence of germline pathogenic variants in Estonian colorectal cancer patients: results from routine clinical setting 2016–2021
por: Roht, Laura, et al.
Publicado: (2022)

A Pathogenic Germline BRCA1 Variant in a Patient With Cellular Congenital Mesoblastic Nephroma: A Case Report
por: Dholakia, Gayatri, et al.
Publicado: (2023)

Mimics of pancreatic ductal adenocarcinoma
por: Al-Hawary, Mahmoud M., et al.
Publicado: (2013)

Pancreatic ductal adenocarcinoma staging
por: Al-Hawary, Mahmoud M., et al.
Publicado: (2013)

Syndecans and Pancreatic Ductal Adenocarcinoma
por: Betriu, Nausika, et al.
Publicado: (2021)

Models of pancreatic ductal adenocarcinoma
por: Dennaoui, Rayane, et al.
Publicado: (2021)

The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma
por: Shui, Lin, et al.
Publicado: (2021)

Case Report: Heterozygous Germline Variant in EIF6 Additional to Biallelic SBDS Pathogenic Variants in a Patient With Ribosomopathy Shwachman–Diamond Syndrome
por: Taha, Ibrahim, et al.
Publicado: (2022)

Splice variants as novel targets in pancreatic ductal adenocarcinoma
por: Wang, Jun, et al.
Publicado: (2017)

BRCA 1/2 Germline Mutation Predicts the Treatment Response of FOLFIRINOX with Pancreatic Ductal Adenocarcinoma in Korean Patients
por: Park, Ji Hoon, et al.
Publicado: (2022)

Pancreatic Ductal Adenocarcinoma Associated with Autoimmune Pancreatitis
por: Pezzilli, Raffaele, et al.
Publicado: (2011)

Germline mutation analyses of malignant ground glass opacity nodules in non-smoking lung adenocarcinoma patients
por: Mao, Wenjun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nh7q489m7bn5ohbm1vssb2087q